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License agreements - Calithera (Details) - USD ($) $ / shares in Units, $ in Thousands, shares in Millions |  |  | 1 Months Ended | 3 Months Ended | 12 Months Ended |
--- | --- | --- | --- | --- | --- | ---
Jan. 01, 2018 | Jan. 30, 2017 | Mar. 31, 2017 | Jan. 31, 2017 | Dec. 31, 2019 | Sep. 30, 2019 | Jun. 30, 2019 | Mar. 31, 2019 | Dec. 31, 2018 | Sep. 30, 2018 | Jun. 30, 2018 | Mar. 31, 2018 | Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2017 | Jan. 01, 2017
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Long term investments |  |  |  |  | $ 133,657 |  |  |  | $ 99,199 |  |  |  | $ 133,657 | $ 99,199 |  |
Research and development expense |  |  |  |  |  |  |  |  |  |  |  |  | 1,154,111 | 1,197,957 | $ 1,326,134 |
Net income |  |  |  |  | 111,005 | $ 128,271 | $ 105,318 | $ 102,312 | 69,063 | $ 29,176 | $ 52,394 | $ (41,140) | 446,906 | 109,493 | (313,142) |
Unrealized gain (loss) on long term investments |  |  |  |  |  |  |  |  |  |  |  |  | 34,458 | (44,093) | (24,275) |
Calithera |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Funding of future development costs (as a percent) |  |  |  | 70.00% |  |  |  |  |  |  |  |  |  |  |  |
Upfront payment made under license agreement |  |  |  | $ 45,000 |  |  |  |  |  |  |  |  |  |  |  |
Potential milestone payments to be made with profit sharing in effect |  |  |  | 430,000 |  |  |  |  |  |  |  |  |  |  |  |
Potential milestone payments to be made with profit sharing terminated |  |  |  | $ 750,000 |  |  |  |  |  |  |  |  |  |  |  |
Milestone payment made under license agreement |  |  | $ 12,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Research and development expense |  |  |  |  |  |  |  |  |  |  |  |  | 17,900 | 12,000 | 23,400 |
Calithera | Accrued and other liabilities |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Accrued and other liabilities |  |  |  |  | 1,100 |  |  |  | 2,600 |  |  |  | 1,100 | 2,600 |  |
Calithera | U.S. |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Percentage of profit (losses) |  |  |  | 60.00% |  |  |  |  |  |  |  |  |  |  |  |
Calithera |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total consideration paid |  | $ 53,000 |  | $ 53,000 |  |  |  |  |  |  |  |  |  |  |  |
Long term investments |  |  |  |  | $ 9,800 |  |  |  | $ 6,900 |  |  |  | $ 9,800 | 6,900 |  |
Ownership percentage (as a percent) |  |  |  |  | 3.00% |  |  |  |  |  |  |  | 3.00% |  |  |
Calithera | Other Comprehensive Income |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Unrealized gain (loss) on long term investments |  |  |  |  |  |  |  |  |  |  |  |  | $ 2,900 | $ (7,500) | 2,800 |
Calithera | Stock purchase agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Purchase of common stock under Stock Purchase Agreement (in shares ) |  |  |  | 1.7 |  |  |  |  |  |  |  |  |  |  |  |
Purchase price of common stock |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 8,000
Per share price |  | $ 6.75 |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 4.65
Fair market value of our long term investments |  | $ 11,600 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock purchase price |  |  |  | $ 8,000 |  |  |  |  |  |  |  |  |  |  |  |
Long term investments |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 11,600 |
Research and development expense |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 41,400 |
Calithera | Collaboration and license agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront license fees |  |  |  | $ 45,000 |  |  |  |  |  |  |  |  |  |  |  |
Calithera | ASU 2016-01 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net income | $ 2,800 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

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