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License agreements - Novartis (Details) - USD ($) $ in Thousands | 1 Months Ended | 3 Months Ended | 12 Months Ended | 122 Months Ended
--- | --- | --- | --- | ---
Apr. 30, 2016 | Sep. 30, 2014 | Jan. 31, 2010 | Dec. 31, 2009 | Nov. 30, 2009 | Dec. 31, 2019 | Sep. 30, 2019 | Jun. 30, 2019 | Mar. 31, 2019 | Dec. 31, 2018 | Sep. 30, 2018 | Jun. 30, 2018 | Mar. 31, 2018 | Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2019
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  | $ 579,389 | $ 551,581 | $ 529,932 | $ 497,857 | $ 528,402 | $ 449,683 | $ 521,516 | $ 382,282 | $ 2,158,759 | $ 1,881,883 | $ 1,536,216 |
Europe |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  |  |  |  |  |  | 90,000 | 79,900 | 66,900 |
U.S. |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,100,000 | 1,800,000 | 1,500,000 |
JAKAFI |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,684,968 | 1,386,964 | 1,133,392 |
Novartis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  |  |  | $ 210,000 |  |  |  |  |  |  |  |  |  |  |  |
Upfront payment received under license agreement |  |  |  | $ 150,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Immediate milestone payment received under license agreement |  |  | $ 60,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  |  |  |  |  |  | 0 | 60,000 | 65,000 |
Reimbursable costs included in accounts receivable |  |  |  |  |  | 400 |  |  |  | 700 |  |  |  | 400 | 700 |  | $ 400
Research and development expenses reimbursed |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,500 | 3,200 | 3,000 |
Product royalties in accounts receivable |  |  |  |  |  | 65,000 |  |  |  | 55,400 |  |  |  | 65,000 | 55,400 |  | 65,000
Novartis | Pre-specified Events | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  |  |  | 1,200,000 |  |  |  |  |  |  |  |  |  |  |  |
Novartis | Development Milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 132,000
Novartis | Development Milestones | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  |  |  | 174,000 |  |  |  |  |  |  |  |  |  |  |  |
Novartis | Regulatory Milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 215,000
Novartis | Regulatory Milestones | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  |  |  | 495,000 |  |  |  |  |  |  |  |  |  |  |  |
Novartis | Commercialization Milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 120,000
Novartis | Commercialization Milestones | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  |  |  | $ 500,000 |  |  |  |  |  |  |  |  |  |  |  |
Novartis | GVHD | Development Milestones | Phase III |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 25,000 |
Novartis | GVHD | Development and Regulatory Milestones | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement | $ 75,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Novartis | JAKAFI | U.S. |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  |  |  |  |  |  | 77,600 | 63,000 | 50,500 |
Royalties payable |  |  |  |  |  | $ 50,200 |  |  |  | $ 18,600 |  |  |  | 50,200 | 18,600 |  | $ 50,200
Novartis | JAKAVI |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 225,900 | 194,700 | 151,700 |
Novartis | JAKAVI | Minimum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  |  |  |  |  |  |  |  |  |  |  |  | 12.00% |  |  |
Novartis | JAKAVI | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  |  |  |  |  |  |  |  |  |  |  |  | 14.00% |  |  |
Novartis | JAKAVI | Regulatory Milestones | Europe |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  | $ 60,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Novartis | JAKAVI | Commercialization Milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 60,000 | 40,000 |
Revenues |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 900,000 | $ 600,000 |

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