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Income Taxes - Reconciliation of income taxes (Details) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2017
Reconciliation of income taxes at the U.S. federal statutory rate to the provision for income taxes |  |  |
Provision (benefit) at U.S. federal statutory rate | $ 102,226 | $ 24,223 | $ (109,302)
Unbenefited net operating losses and tax credits | (82,819) | (51,861) | (99,254)
Excess tax benefits related to share-based compensation | (13,418) | (8,233) | (81,021)
Deferred tax impact of Tax Cuts and Jobs Act of 2017 |  |  | 196,751
Foreign tax rate differential | 25,419 | 37,061 | 86,777
Non-deductible officer compensation | 5,213 | 4,114 | 6,351
Other | 3,264 | 550 | 550
Provision for income taxes | $ 39,885 | $ 5,854 | $ 852
Federal corporate tax rate (as a percent) | 21.00% | 21.00% | 35.00%
Deferred tax assets: |  |  |
Net operating loss carry forwards | $ 102,001 | $ 148,142 |
Federal and state research credits | 400,550 | 402,798 |
Capitalized research and development | 46,188 | 53,871 |
Deferred revenue and accruals | 13,609 | 9,443 |
Non-cash compensation | 67,345 | 58,194 |
Acquisition-related contingent consideration | 31,956 | 43,676 |
Intangibles, net | 92,806 | 93,730 |
Long term investments | 14,899 | 23,621 |
Other | 21,885 | 22,211 |
Total gross deferred tax assets | 791,239 | 855,686 |
Less valuation allowance for deferred tax assets | (770,497) | (836,992) |
Net deferred tax assets | 20,742 | 18,694 |
Deferred tax liabilities: |  |  |
Property and equipment | (19,095) | (17,424) |
Total gross deferred tax liabilities | (19,095) | (17,424) |
Net deferred tax assets | $ 1,647 | $ 1,270 |

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