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License agreements - Lilly (Details) - USD ($) $ in Thousands | 1 Months Ended | 3 Months Ended | 12 Months Ended | 121 Months Ended
--- | --- | --- | --- | ---
May 31, 2019 | Mar. 31, 2016 | Jul. 31, 2010 | Dec. 31, 2009 | Dec. 31, 2019 | Sep. 30, 2019 | Jun. 30, 2019 | Mar. 31, 2019 | Dec. 31, 2018 | Sep. 30, 2018 | Jun. 30, 2018 | Mar. 31, 2018 | Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2019
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Expense |  |  |  |  |  |  |  |  |  |  |  |  | $ 1,154,111 | $ 1,197,957 | $ 1,326,134 |
Revenues |  |  |  |  | $ 579,389 | $ 551,581 | $ 529,932 | $ 497,857 | $ 528,402 | $ 449,683 | $ 521,516 | $ 382,282 | 2,158,759 | 1,881,883 | 1,536,216 |
Europe |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  |  |  |  |  | 90,000 | 79,900 | 66,900 |
Eli Lilly |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront payment received under license agreement |  |  |  | $ 90,000 |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  |  |  |  |  | 0 | 120,000 | 110,000 |
Product royalties in accounts receivable |  |  |  |  | $ 23,600 |  |  |  | 14,000 |  |  |  | 23,600 | 14,000 |  | $ 23,600
Eli Lilly | Non-U.S. |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  |  |  |  |  | $ 80,400 | 40,100 | 9,100 |
Eli Lilly | Phase IIB |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Associated future global development costs from the initiation of a Phase IIb trial, if elected to co-develop (as a percentage) |  |  | 30.00% | 30.00% |  |  |  |  |  |  |  |  | 30.00% |  |  |
Research and Development Expense |  |  |  |  |  |  |  |  |  |  |  |  | $ 0 | 68,600 | 40,800 |
Accrued and other liabilities |  |  |  |  |  |  |  |  | $ 23,100 |  |  |  |  | 23,100 |  |
Eli Lilly | Pre-specified Events | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  |  | $ 665,000 |  |  |  |  |  |  |  |  |  |  |  |
Eli Lilly | Development Milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  |  |  |  |  | 20,000 | 30,000 | 149,000
Eli Lilly | Development Milestones | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  |  | 150,000 |  |  |  |  |  |  |  |  |  |  |  |
Eli Lilly | Regulatory Milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 100,000 |  | $ 235,000
Eli Lilly | Regulatory Milestones | JAPAN |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 15,000 |
Eli Lilly | Regulatory Milestones | Europe |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 65,000 |
Eli Lilly | Regulatory Milestones | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  |  | 365,000 |  |  |  |  |  |  |  |  |  |  |  |
Eli Lilly | Commercialization Milestones | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  |  | $ 150,000 |  |  |  |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  |  |  |  |  |  |  |  |  |  |  | 20.00% |  |  |
Eli Lilly | GVHD |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront payment under license agreement |  | $ 35,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Additional milestone payments under the license agreement |  | $ 40,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Eli Lilly | GVHD | Regulatory Milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone payment made under license agreement | $ 20,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

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