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CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($)
shares in Thousands, $ in Thousands
 12 Months Ended
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Revenues:      
Total revenues $ 2,158,759 $ 1,881,883 $ 1,536,216
Costs and expenses:      
Cost of product revenues (including definite-lived intangible amortization) 114,249 94,123 79,479
Research and development 1,154,111 1,197,957 1,326,134
Selling, general and administrative 468,711 434,407 366,286
Change in fair value of acquisition-related contingent consideration 19,682 26,173 7,704
Total costs and expenses 1,756,753 1,752,660 1,779,603
Income (loss) from operations 402,006 129,223 (243,387)
Other income (expense), net 52,182 31,760 17,153
Interest expense (1,855) (1,543) (6,900)
Unrealized gain (loss) on long term investments 34,458 (44,093) (24,275)
Expense related to senior note conversions     (54,881)
Income (loss) before provision for income taxes 486,791 115,347 (312,290)
Provision for income taxes 39,885 5,854 852
Net income (loss) $ 446,906 $ 109,493 $ (313,142)
Net income (loss) per share:      
Basic $ 2.08 $ 0.52 $ (1.53)
Diluted $ 2.05 $ 0.51 $ (1.53)
Shares used in computing net income (loss) per share:      
Basic 214,913 212,383 204,580
Diluted 217,657 215,635 204,580
Product revenues, net      
Revenues:      
Total revenues $ 1,774,922 $ 1,466,900 $ 1,200,312
Product royalty revenues      
Revenues:      
Total revenues 306,337 234,780 160,791
Milestone and contract revenues      
Revenues:      
Total revenues $ 77,500 180,000 175,000
Other revenues      
Revenues:      
Total revenues   $ 203 $ 113