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Marketable Securities - Fair value on a recurring basis (Details)
$ in Thousands
3 Months Ended 12 Months Ended
Jun. 01, 2016
Dec. 31, 2018
USD ($)
Sep. 30, 2018
USD ($)
Dec. 31, 2019
USD ($)
Dec. 31, 2018
USD ($)
Fair value of financial instruments          
Assets transfers from Level 1 to Level 2       $ 0  
Assets transfers from Level 2 to Level 1       0  
Assets transfers into Level 3       0  
Assets transfers out of Level 3       0  
Liabilities transfers from Level 1 to Level 2       0  
Liabilities transfers from Level 2 to Level 1       0  
Liabilities transfers into Level 3       0  
Liabilities transfers out of Level 3       0  
Long term investments (Note 6)   $ 99,199   133,657 $ 99,199
ARIAD          
Roll forward of Level 3 liabilities          
Contingent consideration earned during the period but not yet paid       23,000 13,200
ARIAD | Contingent Consideration          
Roll forward of Level 3 liabilities          
Projected cash flows period 18 years        
ARIAD | Discount rate | Contingent Consideration          
Roll forward of Level 3 liabilities          
Discount rate (as a percent) 0.10        
ARIAD | Account payable          
Roll forward of Level 3 liabilities          
Contingent consideration earned during the period but not yet paid     $ (6,700)    
ARIAD | Accrued and other current liabilities          
Roll forward of Level 3 liabilities          
Contingent consideration earned during the period but not yet paid   (6,500)      
Level 3 | Fair Value          
Roll forward of Level 3 liabilities          
Balance at the beginning of the period       287,001 287,000
Contingent consideration earned during the period but not yet paid       (23,012) (13,184)
Payments made during the period       (6,671) (12,988)
Change in fair value of contingent consideration       19,682 26,173
Balance at the end of the period   287,001   277,000 287,001
Recurring | Fair Value          
Fair value of financial instruments          
Cash and cash equivalents   1,163,980   1,832,684 1,163,980
Debt securities (corporate and government)   274,343   284,870 274,343
Long term investments (Note 6)   99,199   133,657 99,199
Total assets   1,537,522   2,251,211 1,537,522
Acquisition-related contingent consideration   287,001   277,000 287,001
Total liabilities   287,001   277,000 287,001
Recurring | Level 1          
Fair value of financial instruments          
Cash and cash equivalents   1,163,980   1,832,684 1,163,980
Long term investments (Note 6)   99,199   133,657 99,199
Total assets   1,263,179   1,966,341 1,263,179
Recurring | Level 2          
Fair value of financial instruments          
Debt securities (corporate and government)   274,343   284,870 274,343
Total assets   274,343   284,870 274,343
Recurring | Level 3          
Fair value of financial instruments          
Acquisition-related contingent consideration   287,001   277,000 287,001
Total liabilities   $ 287,001   $ 277,000 $ 287,001