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Stockholders' Equity - Stock options outstanding (Details)	12 Months Ended
	Dec. 31, 2019 $ / shares shares
Options Outstanding
Number Outstanding (in shares) | shares	12,632,657
Options Exercisable
Number Exercisable (in shares) | shares	6,896,492
Range of Exercise Prices $13.34 - $61.75
Stock options outstanding
Exercise price, lower range limit (in dollars per share)	$ 13.34
Exercise price, upper range limit (in dollars per share)	$ 61.75
Options Outstanding
Number Outstanding (in shares) | shares	1,273,143
Weighted Average Remaining Contractual Life	1 year 9 months 7 days
Weighted Average Exercise Price (in dollars per share)	$ 30.33
Options Exercisable
Number Exercisable (in shares) | shares	1,247,056
Weighted Average Exercise Price (in dollars per share)	$ 29.67
Range of Exercise Prices $62.87 - $68.62
Stock options outstanding
Exercise price, lower range limit (in dollars per share)	62.87
Exercise price, upper range limit (in dollars per share)	$ 68.62
Options Outstanding
Number Outstanding (in shares) | shares	1,942,267
Weighted Average Remaining Contractual Life	6 years 5 months 8 days
Weighted Average Exercise Price (in dollars per share)	$ 67.21
Options Exercisable
Number Exercisable (in shares) | shares	1,005,035
Weighted Average Exercise Price (in dollars per share)	$ 66.30
Range of Exercise Prices $68.82 - $68.97
Stock options outstanding
Exercise price, lower range limit (in dollars per share)	68.82
Exercise price, upper range limit (in dollars per share)	$ 68.97
Options Outstanding
Number Outstanding (in shares) | shares	59,644
Weighted Average Remaining Contractual Life	8 years 10 months 2 days
Weighted Average Exercise Price (in dollars per share)	$ 68.95
Options Exercisable
Number Exercisable (in shares) | shares	15,913
Weighted Average Exercise Price (in dollars per share)	$ 68.95
Range of Exercise Prices $72.27 - $72.27
Stock options outstanding
Exercise price, lower range limit (in dollars per share)	72.27
Exercise price, upper range limit (in dollars per share)	$ 72.27
Options Outstanding
Number Outstanding (in shares) | shares	1,929,341
Weighted Average Remaining Contractual Life	8 years 11 months 19 days
Weighted Average Exercise Price (in dollars per share)	$ 72.27
Options Exercisable
Number Exercisable (in shares) | shares	426,451
Weighted Average Exercise Price (in dollars per share)	$ 72.27
Range of Exercise Prices $72.58 - $81.60
Stock options outstanding
Exercise price, lower range limit (in dollars per share)	72.58
Exercise price, upper range limit (in dollars per share)	$ 81.60
Options Outstanding
Number Outstanding (in shares) | shares	1,267,721
Weighted Average Remaining Contractual Life	4 years 6 months 7 days
Weighted Average Exercise Price (in dollars per share)	$ 74.76
Options Exercisable
Number Exercisable (in shares) | shares	938,974
Weighted Average Exercise Price (in dollars per share)	$ 73.70
Range of Exercise Prices $83.58 - $85.01
Stock options outstanding
Exercise price, lower range limit (in dollars per share)	83.58
Exercise price, upper range limit (in dollars per share)	$ 85.01
Options Outstanding
Number Outstanding (in shares) | shares	1,627,376
Weighted Average Remaining Contractual Life	8 years 7 days
Weighted Average Exercise Price (in dollars per share)	$ 84.50
Options Exercisable
Number Exercisable (in shares) | shares	651,669
Weighted Average Exercise Price (in dollars per share)	$ 83.97
Range of Exercise Prices $85.34 - $95.34
Stock options outstanding
Exercise price, lower range limit (in dollars per share)	85.34
Exercise price, upper range limit (in dollars per share)	$ 95.34
Options Outstanding
Number Outstanding (in shares) | shares	1,336,692
Weighted Average Remaining Contractual Life	7 years 8 months 8 days
Weighted Average Exercise Price (in dollars per share)	$ 93.50
Options Exercisable
Number Exercisable (in shares) | shares	508,940
Weighted Average Exercise Price (in dollars per share)	$ 92.76
Range of Exercise Prices $95.54 - $113.64
Stock options outstanding
Exercise price, lower range limit (in dollars per share)	95.54
Exercise price, upper range limit (in dollars per share)	$ 113.64
Options Outstanding
Number Outstanding (in shares) | shares	2,263,583
Weighted Average Remaining Contractual Life	5 years 5 months 26 days
Weighted Average Exercise Price (in dollars per share)	$ 105.46
Options Exercisable
Number Exercisable (in shares) | shares	1,470,017
Weighted Average Exercise Price (in dollars per share)	$ 104.02
Range of Exercise Prices $115.19 - $134.38
Stock options outstanding
Exercise price, lower range limit (in dollars per share)	115.19
Exercise price, upper range limit (in dollars per share)	$ 134.38
Options Outstanding
Number Outstanding (in shares) | shares	906,782
Weighted Average Remaining Contractual Life	7 years 25 days
Weighted Average Exercise Price (in dollars per share)	$ 128.16
Options Exercisable
Number Exercisable (in shares) | shares	615,041
Weighted Average Exercise Price (in dollars per share)	$ 128.42
Range of Exercise Prices $138.52 - $138.52
Stock options outstanding
Exercise price, lower range limit (in dollars per share)	138.52
Exercise price, upper range limit (in dollars per share)	$ 138.52
Options Outstanding
Number Outstanding (in shares) | shares	26,108
Weighted Average Remaining Contractual Life	7 years 3 months
Weighted Average Exercise Price (in dollars per share)	$ 138.52
Options Exercisable
Number Exercisable (in shares) | shares	17,396
Weighted Average Exercise Price (in dollars per share)	$ 138.52

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