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Stock Compensation (Details) - USD ($) $ / shares in Units, $ in Millions	12 Months Ended
	Dec. 31, 2019	Dec. 31, 2018	Dec. 31, 2017
Stock compensation
Stock compensation expense	$ 166.6	$ 148.2	$ 133.1
Stock Compensation Expense Capitalized	$ 0.4	0.1
Weighted-average fair value assumptions
Valuation method	Black-Scholes valuation model
Dividend yield (as a percent)	0.00%
Research and Development Expense [Member]
Stock compensation
Stock compensation expense	$ 114.0	101.1	90.4
Selling, General and Administrative Expenses [Member]
Stock compensation
Stock compensation expense	51.9	47.1	42.7
Cost of product revenues
Stock compensation
Stock compensation expense	0.7
Employee Stock
Stock compensation
Stock compensation expense	$ 3.4	$ 3.7	$ 3.2
Weighted-average fair value assumptions
Average risk-free interest rates (as a percent)	1.82%	2.62%	1.53%
Average expected life (in years)	6 months	6 months	6 months
Volatility (as a percent)	31.00%	46.00%	38.00%
Weighted-average fair value (in dollars per share)	$ 14.04	$ 15.80	$ 19.42
Stock Options
Stock compensation
Assumed annualized forfeiture rate (as a percent)	5.00%
Weighted-average fair value assumptions
Average risk-free interest rates (as a percent)	2.27%	2.61%	1.80%
Average expected life (in years)	5 years 3 months 7 days	5 years 3 months 3 days	5 years 3 months
Volatility (as a percent)	45.00%	45.00%	49.00%
Weighted-average fair value (in dollars per share)	$ 32.38	$ 34.20	$ 53.41
Unrecognized compensation
Unrecognized compensation cost for nonvested option (in dollars)	$ 95.3
Vesting period of recognition of the unrecognized compensation cost of nonvested awards	1 year 6 months
Restricted Stock Units (RSUs)
Stock compensation
Assumed annualized forfeiture rate (as a percent)	5.00%
Unrecognized compensation
Unrecognized compensation cost for nonvested option (in dollars)	$ 86.0
Vesting period of recognition of the unrecognized compensation cost of nonvested awards	1 year 8 months 12 days
Performance Stock Units (PSUs)
Stock compensation
Assumed annualized forfeiture rate (as a percent)	5.00%
Unrecognized compensation
Unrecognized compensation cost for nonvested option (in dollars)	$ 32.0
Vesting period of recognition of the unrecognized compensation cost of nonvested awards	2 years 1 month 6 days

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