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Income Taxes - Tax Credit Carryforwards (Details)
$ in Thousands
Dec. 31, 2019
USD ($)
Orphan drug tax credit carryforwards  
Tax Credit Carryforward  
Tax credit carryforward $ 212,410
Federal | Research and development  
Tax Credit Carryforward  
Tax credit carryforward 187,821
State | Research and development  
Tax Credit Carryforward  
Tax credit carryforward $ 28,664