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License agreements - MorphoSys (Details) $ / shares in Units, $ in Thousands, € in Millions |  | 1 Months Ended | 3 Months Ended | 6 Months Ended |
--- | --- | --- | --- | --- | ---
Mar. 03, 2020 USD ($) $ / shares | Mar. 31, 2020 EUR (€) | Jan. 31, 2020 USD ($) $ / shares | Jun. 30, 2020 USD ($) | Jun. 30, 2019 USD ($) | Jun. 30, 2020 USD ($) | Jun. 30, 2019 USD ($) | Dec. 31, 2019 USD ($)
Unrealized gain (loss) on long term investments |  |  |  | $ 72,274 | $ (4,625) | $ 24,142 | $ 16,364 |
Long term investments |  |  |  | 248,731 |  | 248,731 |  | $ 133,657
Research and development expense |  |  |  | 286,601 | $ 289,363 | 1,371,888 | $ 559,908 |
Collaboration loss sharing |  |  |  | 13,253 |  | 15,383 |  |
ADSs |  |  |  |  |  |  |  |
Equity Method Investment, Ownership Percentage |  |  | 25.00% |  |  |  |  |
Equity Method Investment, Aggregate Cost |  |  | $ 150,000 |  |  |  |  |
Per share price | $ / shares | $ 27.65 |  | $ 41.33 |  |  |  |  |
Lock-up period |  |  | 18 months |  |  |  |  |
Discount for lack of marketability | $ 4,900 |  |  |  |  |  |  |
Fair value of shares | 95,500 |  |  |  |  |  |  |
Long term investments | 95,500 |  |  | $ 113,100 |  | $ 113,100 |  |
Research and development expense | $ 54,500 |  |  |  |  |  |  |
MorphoSys AG |  |  |  |  |  |  |  |
Upfront payment under license agreement | € |  | € 750.0 |  |  |  |  |  |
Equity Method Investment, Ownership Percentage |  |  |  | 3.00% |  | 3.00% |  |
Unrealized gain (loss) on long term investments |  |  |  | $ 27,500 |  | $ 17,600 |  |
Research and development expense |  |  |  | 15,700 |  | $ 27,300 |  |
Associated future global development costs from the initiation of a Phase IIb trial, if elected to co-develop (as a percentage) |  |  |  |  |  | 55.00% |  |
Accrued and other liabilities |  |  |  | 37,500 |  | $ 37,500 |  |
Profit (loss) sharing ratio |  |  |  |  |  | 50.00% |  |
Collaboration loss sharing |  |  |  | $ 13,300 |  | $ 15,400 |  |
MorphoSys AG | Development and Regulatory Milestones | Maximum |  |  |  |  |  |  |  |
Additional milestone payments under the license agreement |  |  | $ 740,000 |  |  |  |  |
MorphoSys AG | Sales and Commercial Milestones | Maximum |  |  |  |  |  |  |  |
Additional milestone payments under the license agreement |  |  | $ 315,000 |  |  |  |  |
MorphoSys AG | MorphoSys AG |  |  |  |  |  |  |  |
Funding of future development costs (as a percent) |  |  |  |  |  | 45.00% |  |
MorphoSys AG | Incyte |  |  |  |  |  |  |  |
Funding of future development costs (as a percent) |  |  |  |  |  | 55.00% |  |

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