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License agreements - Agenus (Details) $ / shares in Units, $ in Thousands, shares in Millions |  |  | 1 Months Ended | 3 Months Ended | 6 Months Ended | 12 Months Ended |  |
--- | --- | --- | --- | --- | --- | --- | --- | ---
Feb. 14, 2017 USD ($) $ / shares | Feb. 01, 2017 USD ($) $ / shares shares | Dec. 31, 2017 USD ($) | Feb. 28, 2017 USD ($) | Nov. 30, 2015 item | Jan. 31, 2015 USD ($) item | Jun. 30, 2020 USD ($) $ / shares shares | Jun. 30, 2019 USD ($) | Jun. 30, 2020 USD ($) $ / shares | Jun. 30, 2019 USD ($) | Dec. 31, 2017 USD ($) | Dec. 31, 2019 USD ($) | Dec. 31, 2018 USD ($)
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Long term investments |  |  |  |  |  |  | $ 248,731 |  | $ 248,731 |  |  | $ 133,657 |
Research and development expense |  |  |  |  |  |  | 286,601 | $ 289,363 | 1,371,888 | $ 559,908 |  |  |
Unrealized gain (loss) on long term investments |  |  |  |  |  |  | 72,274 | (4,625) | 24,142 | 16,364 |  |  |
Current assets |  |  |  |  |  |  | 2,077,625 |  | 2,077,625 |  |  | 2,481,488 |
Current liabilities |  |  |  |  |  |  | 556,513 |  | $ 556,513 |  |  | 513,340 |
Minimum |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  | 15.00% |  |  |  |  |  |  |  |  |  |
Agenus |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Number of program targets | item |  |  |  |  | 3 | 4 |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  |  |  |  |  |  |  | 15.00% |  |  |  |
Upfront payment under license agreement |  |  |  |  |  | $ 60,000 |  |  |  |  |  |  |
Period of notice for termination of license agreement |  |  |  | 12 months |  |  |  |  |  |  |  |  |
Agenus | Development, Regulatory and Commercialization Milestones | Minimum |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  |  |  |  |  |  |  | 6.00% |  |  |  |
Agenus | Development, Regulatory and Commercialization Milestones | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  |  |  |  |  |  |  | 12.00% |  |  |  |
Additional milestone payments under the license agreement |  |  |  | $ 510,000 |  |  |  |  |  |  |  |  |
Agenus | Development Milestones |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront payment under license agreement |  |  |  |  |  |  |  |  |  |  | $ 20,000 |  |
Additional milestone payments under the license agreement |  |  |  |  |  |  |  |  |  |  |  |  | $ 5,000
Agenus |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Long term investments |  |  |  |  |  |  | 65,100 |  | $ 65,100 |  |  | 72,300 |
Research and development expense |  |  |  |  |  |  | $ 200 | 500 | $ 300 | 900 |  |  |
Shares divested (in shares) | shares |  |  |  |  |  |  | 1.2 |  |  |  |  |  |
Ownership percentage (as a percent) | 18.00% |  |  |  |  |  | 9.80% |  | 9.80% |  |  |  |
Gross proceeds from sale of stock |  |  |  |  |  |  | $ 4,500 |  |  |  |  |  |
Unrealized gain (loss) on long term investments |  |  |  |  |  |  | 26,200 | $ 500 | $ (2,700) | $ 11,000 |  |  |
Agenus | Accrued and other liabilities |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Accrued and other liabilities |  |  |  |  |  |  | $ 1,500 |  | $ 1,500 |  |  | $ 1,600 |
Agenus | Minimum |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Share price (per share) | $ / shares |  |  |  |  |  |  | $ 3.57 |  | $ 3.57 |  |  |  |
Agenus | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Share price (per share) | $ / shares |  |  |  |  |  |  | $ 4.21 |  | $ 4.21 |  |  |  |
Agenus | Stock purchase agreement |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Purchase of common stock under Stock Purchase Agreement (in shares ) | shares |  | 10.0 |  |  |  |  |  |  |  |  |  |  |
Purchase price of common stock |  | $ 60,000 |  |  |  |  |  |  |  |  |  |  |
Per share price | $ / shares | $ 4.40 | $ 6.00 |  |  |  |  |  |  |  |  |  |  |
Discount for lack of marketability | $ 4,500 |  |  |  |  |  |  |  |  |  |  |  |
Fair value of shares on the issuance date | 39,500 |  |  |  |  |  |  |  |  |  |  |  |
Total consideration paid | $ 60,000 |  |  |  |  |  |  |  |  |  |  |  |
Long term investments |  |  | $ 39,500 |  |  |  |  |  |  |  | 39,500 |  |
Research and development expense |  |  |  |  |  |  |  |  |  |  | $ 20,500 |  |

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