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License agreements - Merus (Details) $ / shares in Units, $ in Thousands, € in Millions, shares in Millions |  | 1 Months Ended | 3 Months Ended | 6 Months Ended | 12 Months Ended |
--- | --- | --- | --- | --- | --- | ---
Jan. 23, 2017 USD ($) $ / shares | Dec. 31, 2017 | Feb. 28, 2017 USD ($) | Jan. 31, 2017 USD ($) | Dec. 31, 2016 USD ($) $ / shares shares | Jun. 30, 2020 USD ($) | Mar. 31, 2020 EUR (€) | Jun. 30, 2019 USD ($) | Jun. 30, 2020 USD ($) | Jun. 30, 2019 USD ($) | Dec. 31, 2017 USD ($) | Dec. 31, 2019 USD ($)
License agreements |  |  |  |  |  |  |  |  |  |  |  |
Long term investments |  |  |  |  |  | $ 248,731 |  |  | $ 248,731 |  |  | $ 133,657
Research and development expense |  |  |  |  |  | 286,601 |  | $ 289,363 | 1,371,888 | $ 559,908 |  |
Unrealized gain (loss) on long term investments |  |  |  |  |  | 72,274 |  | (4,625) | 24,142 | 16,364 |  |
Current assets |  |  |  |  |  | 2,077,625 |  |  | 2,077,625 |  |  | 2,481,488
Current liabilities |  |  |  |  |  | 556,513 |  |  | 556,513 |  |  | 513,340
Minimum |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  | 15.00% |  |  |  |  |  |  |  |  |  |
Merus |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |
Associated future global development costs , if elected to co-develop (as a percent) |  |  |  | 35.00% |  |  |  |  |  |  |  |
Upfront payment under license agreement |  |  | $ 120,000 |  |  |  |  |  |  |  |  |
Research and development expense |  |  |  |  |  | 1,900 |  | 1,700 | 4,200 | 4,300 |  |
Merus | Accrued and other liabilities |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |
Accrued and other liabilities |  |  |  |  |  | 2,000 |  |  | 2,000 |  |  | 1,600
Merus | U.S. |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |
Profit sharing (as a percent) |  |  |  | 50.00% |  |  |  |  |  |  |  |
Percentage of profit (losses) |  |  |  | 50.00% |  |  |  |  |  |  |  |
Merus | Minimum |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  |  | 6.00% |  |  |  |  |  |  |  |
Merus | Minimum | U.S. |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  |  | 6.00% |  |  |  |  |  |  |  |
Merus | Minimum | Non-U.S. |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  |  | 6.00% |  |  |  |  |  |  |  |
Merus | Maximum |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  |  | 10.00% |  |  |  |  |  |  |  |
Percentage of reverse royalty |  |  |  | 4.00% |  |  |  |  |  |  |  |
Merus | Maximum | U.S. |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  |  | 10.00% |  |  |  |  |  |  |  |
Percentage of additional royalties |  |  |  | 4.00% |  |  |  |  |  |  |  |
Merus | Maximum | Non-U.S. |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  |  | 10.00% |  |  |  |  |  |  |  |
Merus | Maximum | Development and Regulatory Milestones |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |
Additional milestone payments under the license agreement |  |  |  | $ 100,000 |  |  |  |  |  |  |  |
Merus | Maximum | Sales and Commercial Milestones |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |
Additional milestone payments under the license agreement |  |  |  | $ 250,000 |  |  |  |  |  |  |  |
Merus |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |
Per share price of common stock | $ / shares | $ 24.50 |  |  |  |  |  |  |  |  |  |  |
Discount for lack of marketability | $ 5,600 |  |  |  |  |  |  |  |  |  |  |
Fair value of shares on the issuance date | 72,800 |  |  |  |  |  |  |  |  |  |  |
Total consideration paid | 80,000 |  |  |  |  |  |  |  |  |  |  |
Long term investments | $ 72,800 |  |  |  |  |  |  |  |  |  |  |
Research and development expense |  |  |  |  |  |  |  |  |  |  | $ 7,200 |
Fair market value of our long term investments |  |  |  |  |  | $ 51,500 |  |  | $ 51,500 |  |  | $ 45,100
Ownership percentage (as a percent) |  |  |  |  |  | 11.00% |  |  | 11.00% |  |  |
Unrealized gain (loss) on long term investments |  |  |  |  |  | $ 12,700 |  | $ (400) | $ 6,400 | $ 2,100 |  |
Total revenues | € |  |  |  |  |  |  | € 6.3 |  |  |  |  |
Net loss | € |  |  |  |  |  |  | € (16.5) |  |  |  |  |
Merus | Stock purchase agreement |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |
Purchase of common stock under Stock Purchase Agreement (in shares ) | shares |  |  |  |  | 3.2 |  |  |  |  |  |  |
Purchase price of common stock |  |  |  |  | $ 80,000 |  |  |  |  |  |  |
Per share price | $ / shares |  |  |  |  | $ 25.00 |  |  |  |  |  |  |

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