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License agreements - Novartis (Details) - USD ($) $ in Thousands | 1 Months Ended | 3 Months Ended | 6 Months Ended | 128 Months Ended |
--- | --- | --- | --- | --- | ---
Jun. 30, 2020 | May 31, 2020 | Dec. 31, 2017 | Apr. 30, 2016 | Sep. 30, 2014 | Jan. 31, 2010 | Dec. 31, 2009 | Nov. 30, 2009 | Jun. 30, 2020 | Jun. 30, 2019 | Jun. 30, 2020 | Jun. 30, 2019 | Jun. 30, 2020 | Dec. 31, 2019
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  | $ 688,043 | $ 529,932 | $ 1,256,550 | $ 1,027,789 |  |
Minimum |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  | 15.00% |  |  |  |  |  |  |  |  |  |  |
JAKAFI |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  | 473,706 | 409,506 | 933,185 | 785,117 |  |
Novartis |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  |  |  |  |  |  | $ 210,000 |  |  |  |  |  |
Upfront payment received under license agreement |  |  |  |  |  |  | $ 150,000 |  |  |  |  |  |  |
Immediate milestone payment received under license agreement |  |  |  |  |  | $ 60,000 |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  | 90,000 | 0 | 90,000 | 0 |  |
Royalties payable | $ 70,700 |  |  |  |  |  |  |  | 70,700 |  | 70,700 |  | $ 70,700 | $ 50,200
Reimbursable costs included in accounts receivable | 100 |  |  |  |  |  |  |  | 100 |  | 100 |  | 100 | $ 400
Research and development expenses reimbursed |  |  |  |  |  |  |  |  | 0 | 400 | 300 | 1,000 |  |
Novartis | Pre-specified Events | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  |  |  |  |  |  | 1,200,000 |  |  |  |  |  |
Novartis | Development Milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  |  |  |  | 157,000 |
Novartis | Development Milestones | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  |  |  |  |  |  | 174,000 |  |  |  |  |  |
Novartis | Regulatory Milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  |  |  |  | 280,000 |
Novartis | Regulatory Milestones | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  |  |  |  |  |  | 495,000 |  |  |  |  |  |
Novartis | Sales and Commercial Milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  |  |  |  | $ 120,000 |
Novartis | Sales and Commercial Milestones | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  |  |  |  |  |  | $ 500,000 |  |  |  |  |  |
Novartis | TABRECTA |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  | 700 |  | 700 |  |  |
Novartis | TABRECTA | Development Milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  | $ 25,000 |  |  |  |  |  |  |  |  |  |  |  |
Novartis | TABRECTA | Regulatory Milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  | $ 45,000 |  |  |  |  |  |  |  |  |  |  |  |
Novartis | TABRECTA | Regulatory Milestones | JAPAN |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone | $ 20,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Novartis | GVHD | Development and Regulatory Milestones | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  |  | $ 75,000 |  |  |  |  |  |  |  |  |  |
Novartis | JAKAFI | U.S. |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |
Royalties payable on net sales |  |  |  |  |  |  |  |  | 23,200 | 20,100 | 40,700 | 33,500 |  |
Novartis | JAKAVI |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  | $ 66,200 | $ 56,900 | $ 122,600 | $ 102,500 |  |
Novartis | JAKAVI | Minimum |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  |  |  |  |  |  |  |  |  | 12.00% |  |  |
Novartis | JAKAVI | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  |  |  |  |  |  |  |  |  | 14.00% |  |  |
Novartis | JAKAVI | Regulatory Milestones | Europe |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  | $ 60,000 |  |  |  |  |  |  |  |  |

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