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License agreements - Agenus (Details) $ / shares in Units, $ in Thousands, shares in Millions |  |  | 1 Months Ended | 3 Months Ended | 9 Months Ended | 12 Months Ended |  |
--- | --- | --- | --- | --- | --- | --- | --- | ---
Feb. 14, 2017 USD ($) $ / shares | Feb. 01, 2017 USD ($) $ / shares shares | Dec. 31, 2017 USD ($) | Feb. 28, 2017 USD ($) | Nov. 30, 2015 item | Jan. 31, 2015 USD ($) item | Sep. 30, 2020 USD ($) $ / shares shares | Jun. 30, 2020 USD ($) $ / shares shares | Sep. 30, 2019 USD ($) | Sep. 30, 2020 USD ($) $ / shares | Sep. 30, 2019 USD ($) | Dec. 31, 2017 USD ($) | Dec. 31, 2019 USD ($) | Dec. 31, 2018 USD ($)
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |
Long term investments |  |  |  |  |  |  | $ 222,810 |  |  | $ 222,810 |  |  | $ 133,657 |
Research and development expense |  |  |  |  |  |  | 438,109 |  | $ 281,336 | 1,809,997 | $ 841,244 |  |  |
Unrealized gain (loss) on long term investments |  |  |  |  |  |  | (13,207) |  | 2,339 | 10,935 | 18,703 |  |  |
Total revenues |  |  |  |  |  |  | 620,643 |  | 551,581 | 1,877,193 | 1,579,370 |  |  |
Net income |  |  |  |  |  |  |  |  |  | (445,547) | 335,901 |  |  |
Current assets |  |  |  |  |  |  | 2,159,425 |  |  | 2,159,425 |  |  | 2,481,488 |
Current liabilities |  |  |  |  |  |  | 606,202 |  |  | $ 606,202 |  |  | 513,340 |
Minimum |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  | 15.00% |  |  |  |  |  |  |  |  |  |  |
Agenus |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of program targets | item |  |  |  |  | 3 | 4 |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  |  |  |  |  |  |  |  | 15.00% |  |  |  |
Upfront payment under license agreement |  |  |  |  |  | $ 60,000 |  |  |  |  |  |  |  |
Period of notice for termination of license agreement |  |  |  | 12 months |  |  |  |  |  |  |  |  |  |
Agenus | Development, Regulatory and Commercialization Milestones | Minimum |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  |  |  |  |  |  |  |  | 6.00% |  |  |  |
Agenus | Development, Regulatory and Commercialization Milestones | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  |  |  |  |  |  |  |  | 12.00% |  |  |  |
Additional milestone payments under the license agreement |  |  |  | $ 510,000 |  |  |  |  |  |  |  |  |  |
Agenus | Development Milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront payment under license agreement |  |  |  |  |  |  |  |  |  |  |  | $ 20,000 |  |
Additional milestone payments under the license agreement |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 5,000
Agenus |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |
Long term investments |  |  |  |  |  |  | 56,200 |  |  | $ 56,200 |  |  | 72,300 |
Research and development expense |  |  |  |  |  |  | $ 100 |  | 400 | $ 400 | 1,300 |  |  |
Shares divested (in shares) | shares |  |  |  |  |  |  | 2.5 | 1.2 |  |  |  |  |  |
Ownership percentage (as a percent) | 18.00% |  |  |  |  |  | 7.70% | 9.80% |  | 7.70% |  |  |  |
Gross proceeds from sale of stock |  |  |  |  |  |  | $ 12,700 | $ 4,500 |  |  |  |  |  |
Unrealized gain (loss) on long term investments |  |  |  |  |  |  | 3,900 |  | $ (7,500) | $ (1,200) | $ 3,500 |  |  |
Agenus | Accrued and other liabilities |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |
Accrued and other liabilities |  |  |  |  |  |  | $ 1,500 |  |  | $ 1,500 |  |  | $ 1,600 |
Agenus | Minimum |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share price (per share) | $ / shares |  |  |  |  |  |  | $ 4.28 | $ 3.57 |  | $ 4.28 |  |  |  |
Agenus | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share price (per share) | $ / shares |  |  |  |  |  |  | $ 5.25 | $ 4.21 |  | $ 5.25 |  |  |  |
Agenus | Stock purchase agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |
Purchase of common stock under Stock Purchase Agreement (in shares ) | shares |  | 10.0 |  |  |  |  |  |  |  |  |  |  |  |
Purchase price of common stock |  | $ 60,000 |  |  |  |  |  |  |  |  |  |  |  |
Per share price | $ / shares | $ 4.40 | $ 6.00 |  |  |  |  |  |  |  |  |  |  |  |
Discount for lack of marketability | $ 4,500 |  |  |  |  |  |  |  |  |  |  |  |  |
Fair value of shares on the issuance date | 39,500 |  |  |  |  |  |  |  |  |  |  |  |  |
Total consideration paid | $ 60,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Long term investments |  |  | $ 39,500 |  |  |  |  |  |  |  |  | 39,500 |  |
Research and development expense |  |  |  |  |  |  |  |  |  |  |  | $ 20,500 |  |

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