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CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2020
Sep. 30, 2019
Sep. 30, 2020
Sep. 30, 2019
Revenues:        
Total revenues $ 620,643 $ 551,581 $ 1,877,193 $ 1,579,370
Costs and expenses:        
Cost of product revenues (including definite-lived intangible amortization) 34,322 30,040 95,005 82,034
Research and development 438,109 281,336 1,809,997 841,244
Selling, general and administrative 120,788 102,608 349,934 332,534
Change in fair value of acquisition-related contingent consideration 7,109 3,281 19,790 16,560
Collaboration loss sharing 14,989   30,372  
Total costs and expenses 615,317 417,265 2,305,098 1,272,372
Income (loss) from operations 5,326 134,316 (427,905) 306,998
Other income (expense), net 4,917 11,961 18,396 36,334
Interest expense (544) (597) (1,746) (1,248)
Unrealized gain (loss) on long term investments (13,207) 2,339 10,935 18,703
Income (loss) before provision for income taxes (3,508) 148,019 (400,320) 360,787
Provision for income taxes 11,695 19,748 45,227 24,886
Net (loss) income $ (15,203) $ 128,271 $ (445,547) $ 335,901
Net income (loss) per share:        
Basic $ (0.07) $ 0.60 $ (2.05) $ 1.57
Diluted $ (0.07) $ 0.59 $ (2.05) $ 1.55
Shares used in computing net income (loss) per share:        
Basic 218,784 215,199 217,684 214,628
Diluted 218,784 217,791 217,684 217,393
Product revenues, net        
Revenues:        
Total revenues $ 522,252 $ 453,998 $ 1,509,269 $ 1,284,144
Product royalty revenues        
Revenues:        
Total revenues $ 98,391 80,083 272,924 217,726
Milestone revenues        
Revenues:        
Total revenues   $ 17,500 $ 95,000 $ 77,500