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License agreements - MacroGenics (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 9 Months Ended
Sep. 30, 2020
Nov. 30, 2018
Sep. 30, 2018
Dec. 31, 2017
Sep. 30, 2020
Sep. 30, 2019
Sep. 30, 2020
Sep. 30, 2019
Dec. 31, 2019
License agreements                  
Research and development         $ 438,109 $ 281,336 $ 1,809,997 $ 841,244  
MacroGenics                  
License agreements                  
Upfront payment under license agreement       $ 150,000          
Research and development   $ 5,000 $ 10,000   10,600 $ 14,100 43,300 $ 33,300  
Milestone payment made under license agreement $ 15,000                
MacroGenics | Accrued and other liabilities                  
License agreements                  
Accrued and other liabilities $ 300       $ 300   $ 300   $ 1,000
Minimum                  
License agreements                  
Royalty payments on future global net sales (as a percent)       15.00%          
Maximum | MacroGenics                  
License agreements                  
Royalty payments on future global net sales (as a percent)       24.00%          
Development and Regulatory Milestones | Maximum | MacroGenics                  
License agreements                  
Additional milestone payments under the license agreement       $ 420,000          
Sales and Commercial Milestones | Maximum | MacroGenics                  
License agreements                  
Additional milestone payments under the license agreement       $ 330,000