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Stock compensation (Details) - USD ($) $ / shares in Units, $ in Millions	3 Months Ended		9 Months Ended
	Sep. 30, 2020	Sep. 30, 2019	Sep. 30, 2020	Sep. 30, 2019
Stock compensation
Stock compensation expense	$ 43.8	$ 43.4	$ 132.6	$ 124.6
Stock Compensation Expense Capitalized	0.2	0.1	$ 0.5	0.3
Assumed annualized forfeiture rate (as a percent)			5.00%
Weighted-average fair value assumptions
Valuation method			Black-Scholes valuation model
Research and Development Expense
Stock compensation
Stock compensation expense	29.0	30.5	$ 90.2	85.5
Selling, General and Administrative Expenses
Stock compensation
Stock compensation expense	14.6	12.8	41.7	38.6
Cost of product revenues
Stock compensation
Stock compensation expense	$ 0.2	$ 0.1	$ 0.7	$ 0.5
Stock Options
Weighted-average fair value assumptions
Average risk-free interest rates (as a percent)	0.28%	1.74%	0.85%	2.29%
Average expected life (in years)	5 years 1 month 24 days	5 years 1 month 2 days	4 years 11 months 15 days	5 years 3 months 10 days
Volatility (as a percent)	39.00%	45.00%	40.00%	45.00%
Weighted-average fair value (in dollars per share)	$ 36.73	$ 34.83	$ 32.79	$ 32.38
Unrecognized compensation
Unrecognized compensation cost for nonvested option (in dollars)	$ 89.6		$ 89.6
Vesting period of recognition of the unrecognized compensation cost of nonvested awards			1 year 3 months 18 days
Restricted Stock Units (RSUs)
Weighted-average fair value assumptions
Average risk-free interest rates (as a percent)	0.13%	1.63%	0.17%	1.94%
Average expected life (in years)	6 months	6 months	6 months	6 months
Volatility (as a percent)	38.00%	34.00%	46.00%	34.00%
Weighted-average fair value (in dollars per share)	$ 22.83	$ 15.04	$ 19.07	$ 14.53
Unrecognized compensation
Unrecognized compensation cost for nonvested option (in dollars)	$ 139.0		$ 139.0
Vesting period of recognition of the unrecognized compensation cost of nonvested awards			1 year 10 months 24 days
Performance Stock Units (PSUs)
Unrecognized compensation
Unrecognized compensation cost for nonvested option (in dollars)	$ 26.9		$ 26.9
Vesting period of recognition of the unrecognized compensation cost of nonvested awards			1 year 7 months 6 days

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