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License Agreements - Lilly (Details) - USD ($) $ in Thousands | 1 Months Ended | 3 Months Ended | 12 Months Ended | 133 Months Ended
--- | --- | --- | --- | ---
May 31, 2019 | Mar. 31, 2016 | Jul. 31, 2010 | Dec. 31, 2009 | Dec. 31, 2020 | Sep. 30, 2020 | Jun. 30, 2020 | Mar. 31, 2020 | Dec. 31, 2019 | Sep. 30, 2019 | Jun. 30, 2019 | Mar. 31, 2019 | Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2020
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Expense |  |  |  |  |  |  |  |  |  |  |  |  | $ 2,215,942 | $ 1,154,111 | $ 1,197,957 |
Revenues |  |  |  |  | $ 789,509 | $ 620,643 | $ 688,043 | $ 568,507 | $ 579,389 | $ 551,581 | $ 529,932 | $ 497,857 | 2,666,702 | 2,158,759 | 1,881,883 |
Europe |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  |  |  |  |  | 105,000 | 90,000 | 79,900 |
Product royalty revenues |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  | $ 119,900 | $ 98,400 | $ 92,800 | $ 81,800 | $ 88,600 | $ 80,100 | $ 76,000 | $ 61,600 | 392,966 | 306,337 | 234,780 |
Eli Lilly |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront payment received under license agreement |  |  |  | $ 90,000 |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  |  |  |  |  | 30,000 | 0 | 120,000 |
Eli Lilly | Non-U.S. |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  |  |  |  |  | $ 110,900 | 80,400 | 40,100 |
Eli Lilly | Phase IIB |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Associated future global development costs from the initiation of a Phase IIb trial, if elected to co-develop (as a percentage) |  |  | 30.00% | 30.00% |  |  |  |  |  |  |  |  | 30.00% |  |  |
Research and Development Expense |  |  |  |  |  |  |  |  |  |  |  |  | $ 0 | $ 0 | 68,600 |
Eli Lilly | Pre-specified Events | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  |  | $ 665,000 |  |  |  |  |  |  |  |  |  |  |  |
Eli Lilly | Development Milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 20,000 | $ 149,000
Eli Lilly | Development Milestones | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  |  | 150,000 |  |  |  |  |  |  |  |  |  |  |  |
Eli Lilly | Regulatory Milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 100,000 | $ 265,000
Eli Lilly | Regulatory Milestones | JAPAN |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  |  |  |  | 10,000 |  |  |
Eli Lilly | Regulatory Milestones | Europe |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  |  |  |  | $ 20,000 |  |  |
Eli Lilly | Regulatory Milestones | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  |  | 365,000 |  |  |  |  |  |  |  |  |  |  |  |
Eli Lilly | Sales and Commercial Milestones | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  |  | $ 150,000 |  |  |  |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  |  |  |  |  |  |  |  |  |  |  | 20.00% |  |  |
Eli Lilly | GVHD |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront payment under license agreement |  | $ 35,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Additional milestone payments under the license agreement |  | $ 40,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Eli Lilly | GVHD | Regulatory Milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone payment made under license agreement | $ 20,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

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