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Fair Value of Financial Instruments - Fair value on a recurring basis (Details) $ in Thousands |  | 12 Months Ended
--- | --- | ---
Jun. 01, 2016 | Dec. 31, 2020 USD ($) | Dec. 31, 2019 USD ($)
Fair value of financial instruments |  |  |
Long term investments (Note 6) |  | $ 222,301 | $ 133,657
ARIAD | Contingent Consideration |  |  |
Roll forward of Level 3 liabilities |  |  |
Projected cash flows period | 18 years |  |
ARIAD | Discount rate | Contingent Consideration |  |  |
Roll forward of Level 3 liabilities |  |  |
Valuation input (as a percent) | 0.10 |  |
ARIAD | Average Cost of Capital | Contingent Consideration |  |  |
Roll forward of Level 3 liabilities |  |  |
Valuation input (as a percent) |  | 0.10 |
ARIAD | Accrued and other current liabilities |  |  |
Roll forward of Level 3 liabilities |  |  |
Contingent consideration earned during the period but not yet paid |  | $ 9,600 | 23,000
Level 3 | Fair Value |  |  |
Roll forward of Level 3 liabilities |  |  |
Balance at the beginning of the period |  | 277,000 | 287,001
Contingent consideration earned during the period but not yet paid |  | (9,595) | (23,012)
Payments made during the period |  | (24,790) | (6,671)
Change in fair value of contingent consideration |  | 23,385 | 19,682
Balance at the end of the period |  | 266,000 | 277,000
Recurring | Fair Value |  |  |
Fair value of financial instruments |  |  |
Cash and cash equivalents |  | 1,513,008 | 1,832,684
Debt securities (government) |  | 288,369 | 284,870
Long term investments (Note 6) |  | 222,301 | 133,657
Total assets |  | 2,023,678 | 2,251,211
Acquisition-related contingent consideration |  | 266,000 | 277,000
Total liabilities |  | 266,000 | 277,000
Recurring | Level 1 |  |  |
Fair value of financial instruments |  |  |
Cash and cash equivalents |  | 1,513,008 | 1,832,684
Long term investments (Note 6) |  | 222,301 | 133,657
Total assets |  | 1,735,309 | 1,966,341
Recurring | Level 2 |  |  |
Fair value of financial instruments |  |  |
Debt securities (government) |  | 288,369 | 284,870
Total assets |  | 288,369 | 284,870
Recurring | Level 3 |  |  |
Fair value of financial instruments |  |  |
Acquisition-related contingent consideration |  | 266,000 | 277,000
Total liabilities |  | $ 266,000 | $ 277,000

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