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Accrued and Other Current Liabilities (Details) - USD ($) $ in Thousands | Dec. 31, 2020 | Dec. 31, 2019
--- | --- | ---
Accrued and Other Current Liabilities |  |
Royalties | $ 106,011 | $ 73,221
Clinical related costs | 115,897 | 88,710
Sales allowances | 73,204 | 59,924
Construction in progress | 22,807 | 12,732
Operating lease liabilities | 12,674 | 9,343
Other current liabilities | 47,811 | 42,049
Total accrued and other current liabilities | $ 378,404 | $ 285,979

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