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Income Taxes - Reconciliation of income taxes (Details) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018
Reconciliation of income taxes at the U.S. federal statutory rate to the provision for income taxes |  |  |
Provision (benefit) at U.S. federal statutory rate | $ (48,766) | $ 102,226 | $ 24,223
Unbenefited net operating losses and tax credits | 105,923 | (73,666) | (51,861)
Excess tax benefits related to share-based compensation | (9,750) | (13,418) | (8,233)
Foreign tax rate differential | 30,412 | 25,419 | 37,061
Non-deductible officer compensation | 7,418 | 5,213 | 4,114
Foreign-derived intangible income | (22,830) | (9,153) |
Other | 1,072 | 3,264 | 550
Provision for income taxes | 63,479 | 39,885 | $ 5,854
Deferred tax assets: |  |  |
Net operating loss carry forwards | 128,088 | 102,001 |
Federal and state research credits | 305,099 | 400,550 |
Capitalized research and development | 43,806 | 46,188 |
Deferred revenue and accruals | 27,467 | 13,609 |
Non-cash compensation | 75,867 | 67,345 |
Acquisition-related contingent consideration | 32,658 | 31,956 |
Intangibles, net | 289,848 | 92,806 |
Long term investments | 25,968 | 14,899 |
Other | 26,303 | 21,885 |
Total gross deferred tax assets | 955,104 | 791,239 |
Less valuation allowance for deferred tax assets | (930,209) | (770,497) |
Net deferred tax assets | 24,895 | 20,742 |
Deferred tax liabilities: |  |  |
Property and equipment | (22,841) | (19,095) |
Total gross deferred tax liabilities | (22,841) | (19,095) |
Net deferred tax assets | $ 2,054 | $ 1,647 |

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