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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018
Cash flows from operating activities: |  |  |
Net income (loss) | $ (295,697) | $ 446,906 | $ 109,493
Adjustments to reconcile net income to net cash provided by operating activities: |  |  |
Depreciation and amortization | 51,807 | 54,533 | 54,969
Stock-based compensation | 177,877 | 166,589 | 148,153
Deferred income taxes | (350) | (377) | (459)
Other, net | 546 | 486 | 344
Unrealized gain (loss) on long term investments | (10,426) | (34,458) | 44,093
Change in fair value of acquisition-related contingent consideration | 23,385 | 19,682 | 26,173
Changes in operating assets and liabilities: |  |  |
Accounts receivable | (173,185) | (1,211) | (41,299)
Prepaid expenses and other assets | (8,050) | 5,744 | (33,412)
Inventory | (19,468) | (6,100) | 4,043
Accounts payable | 15,120 | (20,180) | 36,156
Accrued and other liabilities | 113,842 | 79,042 | (12,027)
Net cash (used in) provided by operating activities | (124,599) | 710,656 | 336,227
Cash flows from investing activities: |  |  |
Purchase of long term investments | (95,468) |  | (8,936)
Sale of long term investment | 17,250 |  |
Capital expenditures | (187,379) | (78,064) | (73,483)
Purchases of marketable securities | (516,874) | (374,809) | (159,932)
Sale and maturities of marketable securities | 513,470 | 365,419 | 155,928
Net cash used in investing activities | (269,001) | (87,454) | (86,423)
Cash flows from financing activities: |  |  |
Proceeds from issuance of common stock under stock plans | 110,305 | 63,299 | 29,942
Payment of finance lease liabilities | (836) | (822) |
Payment of contingent consideration | (37,760) | (16,766) | (15,285)
Net cash provided by financing activities | 71,709 | 45,711 | 14,657
Effect of exchange rates on cash, cash equivalents, restricted cash and investments | 2,949 | (192) | 91
Net (decrease) increase in cash, cash equivalents, restricted cash and investments | (318,942) | 668,721 | 264,552
Cash, cash equivalents, restricted cash and investments at beginning of period | 1,833,707 | 1,164,986 | 900,434
Cash, cash equivalents, restricted cash and investments at end of period | 1,514,765 | 1,833,707 | 1,164,986
Supplemental Schedule of Cash Flow Information |  |  |
Interest paid | 194 | 239 | 268
Income taxes paid | 70,712 | 33,553 | 5,417
Unpaid purchases of property and equipment | 22,807 | 12,732 | 7,673
Leased assets obtained in exchange for new operating lease liabilities | 19,908 | 7,607 |
Leased assets obtained in exchange for new finance lease liabilities | 2,160 | $ 29,889 |
Convertible Senior Notes 0.375 Percent Due 2018 |  |  |
Supplemental Schedule of Cash Flow Information |  |  |
Reclassification to common stock and additional paid in capital in connection with conversion/exchange of debt instruments |  |  | $ 7,695
Convertible Senior Notes 1.25 Percent Due 2020 |  |  |
Supplemental Schedule of Cash Flow Information |  |  |
Reclassification to common stock and additional paid in capital in connection with conversion/exchange of debt instruments | $ 18,999 |  |

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