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Property and Equipment, net - Property and equipment, net (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Property and equipment, net
Property and Equipment, gross	$ 703,999	$ 499,437
Less accumulated depreciation and amortization	(144,374)	(121,870)
Property and Equipment, net	559,625	377,567
Depreciation expense including amortization expense of leasehold improvements	29,600	32,100	$ 32,300
Office equipment
Property and equipment, net
Property and Equipment, gross	17,880	15,303
Laboratory equipment
Property and equipment, net
Property and Equipment, gross	86,021	70,510
Computer equipment
Property and equipment, net
Property and Equipment, gross	66,640	59,069
Land
Property and equipment, net
Property and Equipment, gross	10,671	10,203
Building and leasehold improvements
Property and equipment, net
Property and Equipment, gross	238,042	208,293
Operating lease right-of-use assets
Property and equipment, net
Property and Equipment, gross	26,816	19,672
Construction in Progress
Property and equipment, net
Property and Equipment, gross	$ 257,929	$ 116,387

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- Definition

Amount of accumulated depreciation, depletion and amortization for physical assets used in the normal conduct of business to produce goods and services.

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Amount before accumulated depreciation, depletion and amortization of physical assets used in the normal conduct of business and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, and furniture and fixtures.

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