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Stock Compensation (Details) - USD ($) $ / shares in Units, $ in Millions	3 Months Ended
	Mar. 31, 2021	Mar. 31, 2020
Stock compensation
Stock compensation expense	$ 47.3	$ 42.5
Stock Compensation Expense Capitalized	$ 0.5	0.2
Assumed annualized forfeiture rate (as a percent)	5.00%
Weighted-average fair value assumptions
Valuation method	Black-Scholes valuation model
Dividend yield (as a percent)	0.00%
Research and Development Expense
Stock compensation
Stock compensation expense	$ 29.9	28.7
Selling, General and Administrative Expenses
Stock compensation
Stock compensation expense	17.2	13.6
Cost of product revenues
Stock compensation
Stock compensation expense	$ 0.2	$ 0.2
Employee Stock
Weighted-average fair value assumptions
Average risk-free interest rates (as a percent)	0.16%	0.23%
Average expected life (in years)	3 months	3 months
Volatility (as a percent)	39.00%	52.00%
Weighted-average fair value (in dollars per share)	$ 19.08	$ 16.00
Stock Options
Weighted-average fair value assumptions
Average risk-free interest rates (as a percent)	0.34%	1.56%
Average expected life (in years)	4 years 8 months 4 days	4 years 7 months 24 days
Volatility (as a percent)	39.00%	40.00%
Weighted-average fair value (in dollars per share)	$ 29.88	$ 28.43
Unrecognized compensation
Unrecognized compensation cost for nonvested option (in dollars)	$ 78.6
Vesting period of recognition of the unrecognized compensation cost of nonvested awards	1 year 2 months 12 days
Restricted Stock Units (RSUs)
Unrecognized compensation
Unrecognized compensation cost for nonvested option (in dollars)	$ 131.1
Vesting period of recognition of the unrecognized compensation cost of nonvested awards	1 year 9 months 18 days
Performance Stock Units (PSUs)
Unrecognized compensation
Unrecognized compensation cost for nonvested option (in dollars)	$ 23.0
Vesting period of recognition of the unrecognized compensation cost of nonvested awards	1 year 1 month 6 days

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