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CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2021
Jun. 30, 2020
Jun. 30, 2021
Jun. 30, 2020
Revenues:        
Total revenues $ 705,709 $ 688,043 $ 1,310,427 $ 1,256,550
Costs and expenses:        
Cost of product revenues (including definite-lived intangible amortization) 38,028 33,364 67,248 60,683
Research and development 343,511 286,601 650,407 1,371,888
Selling, general and administrative 168,859 117,998 322,654 229,146
Change in fair value of acquisition-related contingent consideration 4,632 6,054 10,158 12,681
Collaboration loss sharing 9,843 13,253 20,327 15,383
Total costs and expenses 564,873 457,270 1,070,794 1,689,781
Income (loss) from operations 140,836 230,773 239,633 (433,231)
Other income (expense), net 4,390 4,817 2,983 13,479
Interest expense (358) (600) (717) (1,202)
Unrealized gain (loss) on long term investments 26,765 72,274 (944) 24,142
Income (loss) before provision for income taxes 171,633 307,264 240,955 (396,812)
Provision for income taxes 22,177 16,966 37,964 33,532
Net income (loss) $ 149,456 $ 290,298 $ 202,991 $ (430,344)
Net income (loss) per share:        
Basic $ 0.68 $ 1.33 $ 0.92 $ (1.98)
Diluted $ 0.67 $ 1.32 $ 0.91 $ (1.98)
Shares used in computing net income (loss) per share:        
Basic 220,083 217,549 219,942 217,135
Diluted 222,250 220,434 222,061 217,135
Product revenues, net        
Revenues:        
Total revenues $ 575,150 $ 500,290 $ 1,079,961 $ 987,017
Product royalty revenues        
Revenues:        
Total revenues 120,559 92,753 220,466 174,533
Milestone revenues        
Revenues:        
Total revenues $ 10,000 $ 95,000 $ 10,000 $ 95,000