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License Agreements - Calithera (Details) - USD ($) $ / shares in Units, $ in Thousands, shares in Millions		1 Months Ended	3 Months Ended		6 Months Ended		12 Months Ended
	Jan. 30, 2017	Jan. 31, 2017	Jun. 30, 2021	Jun. 30, 2020	Jun. 30, 2021	Jun. 30, 2020	Dec. 31, 2017	Dec. 31, 2020	Jan. 01, 2017
License agreements
Long term investments			$ 220,691		$ 220,691			$ 222,301
Research and development expense			343,511	$ 286,601	650,407	$ 1,371,888
Unrealized gain (loss) on long term investments			26,765	72,274	(944)	24,142
Calithera
License agreements
Funding of future development costs (as a percent)		70.00%
Upfront payment made under license agreement		$ 45,000
Potential milestone payments to be made with profit sharing in effect		12,000
Potential milestone payments to be made with profit sharing terminated		$ 738,000
Research and development expense			2,000	1,900	4,500	4,400
Calithera | Accrued and other liabilities
License agreements
Accrued and other liabilities			0		0
Calithera | U.S.
License agreements
Percentage of profit (losses)		60.00%
Calithera
License agreements
Total consideration paid	$ 53,000	$ 53,000
Long term investments			$ 3,600		$ 3,600			8,400
Ownership percentage (as a percent)			2.00%		2.00%
Calithera | Other Comprehensive Income
License agreements
Unrealized gain (loss) on long term investments			$ (500)	$ 1,500	$ (4,800)	$ (700)
Calithera | Calithera | Accrued and other liabilities
License agreements
Accrued and other liabilities								$ 600
Calithera | Stock purchase agreement
License agreements
Purchase of common stock under Stock Purchase Agreement (in shares )		1.7
Purchase price of common stock									$ 8,000
Per share price	$ 6.75								$ 4.65
Fair market value of our long term investments	$ 11,600
Stock purchase price		$ 8,000
Long term investments							$ 11,600
Research and development expense							$ 41,400
Calithera | Collaboration and license agreement
License agreements
Upfront license fees		$ 45,000

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