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Stock Compensation (Details) - USD ($) $ / shares in Units, $ in Millions	3 Months Ended		6 Months Ended
	Jun. 30, 2021	Jun. 30, 2020	Jun. 30, 2021	Jun. 30, 2020
Stock compensation
Stock compensation expense	$ 44.8	$ 46.3	$ 92.1	$ 88.8
Stock Compensation Expense Capitalized	0.7	0.1	$ 1.2	0.3
Assumed annualized forfeiture rate (as a percent)			5.00%
Weighted-average fair value assumptions
Valuation method			Black-Scholes valuation model
Research and Development Expense
Stock compensation
Stock compensation expense	28.0	32.5	$ 57.9	61.2
Selling, General and Administrative Expenses
Stock compensation
Stock compensation expense	16.4	13.6	33.6	27.1
Cost of product revenues
Stock compensation
Stock compensation expense	$ 0.4	$ 0.2	$ 0.6	$ 0.5
Stock Options
Weighted-average fair value assumptions
Average risk-free interest rates (as a percent)	0.75%	0.33%	0.44%	1.32%
Average expected life (in years)	5 years 3 months 25 days	5 years 5 months 23 days	4 years 10 months 2 days	4 years 9 months 18 days
Volatility (as a percent)	38.00%	39.00%	39.00%	40.00%
Weighted-average fair value (in dollars per share)	$ 29.55	$ 34.13	$ 29.80	$ 29.49
Unrecognized compensation
Unrecognized compensation cost for nonvested option (in dollars)	$ 65.3		$ 65.3
Vesting period of recognition of the unrecognized compensation cost of nonvested awards			1 year 1 month 6 days
Restricted Stock Units (RSUs)
Weighted-average fair value assumptions
Average risk-free interest rates (as a percent)	0.25%	0.16%	0.18%	0.19%
Average expected life (in years)	6 months	6 months	6 months	6 months
Volatility (as a percent)	26.00%	38.00%	33.00%	48.00%
Weighted-average fair value (in dollars per share)	$ 16.14	$ 19.50	$ 18.48	$ 17.47
Unrecognized compensation
Unrecognized compensation cost for nonvested option (in dollars)	$ 110.7		$ 110.7
Vesting period of recognition of the unrecognized compensation cost of nonvested awards			1 year 8 months 12 days
Performance Stock Units (PSUs)
Unrecognized compensation
Unrecognized compensation cost for nonvested option (in dollars)	$ 13.5		$ 13.5
Vesting period of recognition of the unrecognized compensation cost of nonvested awards			1 year 2 months 12 days

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