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Fair Value of Financial Instruments - Fair value on a recurring basis (Details)
$ in Thousands
9 Months Ended 12 Months Ended
Jun. 01, 2016
Sep. 30, 2021
USD ($)
Dec. 31, 2020
USD ($)
Fair value of financial instruments      
Long term investments (Note 6)   $ 192,096 $ 222,301
ARIAD | Contingent Consideration      
Roll forward of Level 3 liabilities      
Projected cash flows period 18 years    
ARIAD | Discount rate | Contingent Consideration      
Roll forward of Level 3 liabilities      
Valuation input (as a percent) 10    
ARIAD | Average Cost of Capital | Contingent Consideration      
Roll forward of Level 3 liabilities      
Valuation input (as a percent)   10  
ARIAD | Accrued and other current liabilities      
Roll forward of Level 3 liabilities      
Contingent consideration earned during the period but not yet paid   $ (9,900) (9,600)
Level 3 | Fair Value      
Roll forward of Level 3 liabilities      
Balance at the beginning of the period   266,000  
Contingent consideration earned during the period but not yet paid   (9,910)  
Payments made during the period   (17,158)  
Change in fair value of contingent consideration   13,068  
Balance at the end of the period   252,000 266,000
Recurring | Fair Value      
Fair value of financial instruments      
Cash and cash equivalents   1,999,021 1,513,008
Debt securities (government)   285,054 288,369
Long term investments (Note 6)   192,096 222,301
Total assets   2,476,171 2,023,678
Acquisition-related contingent consideration   252,000 266,000
Total liabilities   252,000 266,000
Recurring | Level 1      
Fair value of financial instruments      
Cash and cash equivalents   1,999,021 1,513,008
Long term investments (Note 6)   192,096 222,301
Total assets   2,191,117 1,735,309
Recurring | Level 2      
Fair value of financial instruments      
Debt securities (government)   285,054 288,369
Total assets   285,054 288,369
Recurring | Level 3      
Fair value of financial instruments      
Acquisition-related contingent consideration   252,000 266,000
Total liabilities   $ 252,000 $ 266,000