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CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2021
Sep. 30, 2020
Sep. 30, 2021
Sep. 30, 2020
Revenues:        
Total revenues $ 812,987 $ 620,643 $ 2,123,414 $ 1,877,193
Costs and expenses:        
Cost of product revenues (including definite-lived intangible amortization) 39,869 34,322 107,117 95,005
Research and development 334,945 438,109 985,352 1,809,997
Selling, general and administrative 190,704 120,788 513,358 349,934
Change in fair value of acquisition-related contingent consideration 2,910 7,109 13,068 19,790
Collaboration loss sharing 9,149 14,989 29,476 30,372
Total costs and expenses 577,577 615,317 1,648,371 2,305,098
Income (loss) from operations 235,410 5,326 475,043 (427,905)
Other income (expense), net 1,948 4,917 4,931 18,396
Interest expense (439) (544) (1,156) (1,746)
Unrealized gain (loss) on long term investments (27,450) (13,207) (28,394) 10,935
Income (loss) before provision for income taxes 209,469 (3,508) 450,424 (400,320)
Provision for income taxes 27,730 11,695 65,694 45,227
Net income (loss) $ 181,739 $ (15,203) $ 384,730 $ (445,547)
Net income (loss) per share:        
Basic $ 0.82 $ (0.07) $ 1.75 $ (2.05)
Diluted $ 0.82 $ (0.07) $ 1.73 $ (2.05)
Shares used in computing net income (loss) per share:        
Basic 220,845 218,784 220,243 217,684
Diluted 222,248 218,784 222,113 217,684
Product revenues, net        
Revenues:        
Total revenues $ 594,013 $ 522,252 $ 1,673,974 $ 1,509,269
Product royalty revenues        
Revenues:        
Total revenues 183,974 $ 98,391 404,440 272,924
Milestone revenues        
Revenues:        
Total revenues $ 35,000   $ 45,000 $ 95,000