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License Agreements - Agenus (Details)
$ / shares in Units, $ in Thousands, shares in Millions
1 Months Ended 3 Months Ended 9 Months Ended 12 Months Ended
Feb. 14, 2017
USD ($)
$ / shares
Feb. 01, 2017
USD ($)
$ / shares
shares
Feb. 28, 2017
USD ($)
Nov. 30, 2015
item
Jan. 31, 2015
USD ($)
item
Sep. 30, 2021
USD ($)
$ / shares
shares
Jun. 30, 2021
USD ($)
$ / shares
shares
Mar. 31, 2021
USD ($)
$ / shares
shares
Sep. 30, 2020
USD ($)
$ / shares
shares
Jun. 30, 2020
USD ($)
$ / shares
shares
Sep. 30, 2021
USD ($)
$ / shares
Sep. 30, 2020
USD ($)
$ / shares
Dec. 31, 2017
USD ($)
Dec. 31, 2020
USD ($)
License agreements                            
Long term investments           $ 192,096         $ 192,096     $ 222,301
Unrealized gain (loss) on long term investments           (27,450)     $ (13,207)   (28,394) $ 10,935    
Research and development expense           334,945     $ 438,109   $ 985,352 1,809,997    
Agenus                            
License agreements                            
Number of program targets | item       3 4                  
Royalty payments on future global net sales (as a percent)                     15.00%      
Upfront payment under license agreement         $ 60,000                  
Period of notice for termination of license agreement     12 months                      
Agenus | Development, Regulatory and Commercialization Milestones | Minimum                            
License agreements                            
Royalty payments on future global net sales (as a percent)                     6.00%      
Agenus | Development, Regulatory and Commercialization Milestones | Maximum                            
License agreements                            
Royalty payments on future global net sales (as a percent)                     12.00%      
Additional milestone payments under the license agreement     $ 500,000                      
Agenus | Development Milestones                            
License agreements                            
Upfront payment under license agreement                         $ 20,000  
Additional milestone payments under the license agreement               $ 10,000            
Agenus                            
License agreements                            
Long term investments           $ 63,400         $ 63,400     44,700
Ownership percentage (as a percent) 18.00%         5.00%         5.00%      
Shares divested (in shares) | shares           0.2 1.6 0.2 2.5 1.2        
Share price (per share) | $ / shares               $ 5.45            
Gross proceeds from sale of stock           $ 1,100 $ 8,200 $ 1,100 $ 12,700 $ 4,500        
Unrealized gain (loss) on long term investments           (2,800)     3,900   $ 29,100 (1,200)    
Research and development expense           200     $ 100   900 $ 400    
Agenus | Accrued and other liabilities                            
License agreements                            
Accrued and other liabilities           $ 800         $ 800     $ 500
Agenus | Minimum                            
License agreements                            
Share price (per share) | $ / shares           $ 5.74 $ 4.59   $ 4.28 $ 3.57 $ 5.74 $ 4.28    
Agenus | Maximum                            
License agreements                            
Share price (per share) | $ / shares           $ 6.75 $ 5.41   $ 5.25 $ 4.21 $ 6.75 $ 5.25    
Agenus | Stock purchase agreement                            
License agreements                            
Total consideration paid $ 60,000                          
Purchase of common stock under Stock Purchase Agreement (in shares ) | shares   10.0                        
Purchase price of common stock   $ 60,000                        
Per share price | $ / shares $ 4.40 $ 6.00                        
Discount for lack of marketability $ 4,500                          
Fair value of shares on the issuance date $ 39,500                          
Long term investments                         39,500  
Research and development expense                         $ 20,500