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Stock Compensation (Details) - USD ($) $ / shares in Units, $ in Millions	3 Months Ended		9 Months Ended
	Sep. 30, 2021	Sep. 30, 2020	Sep. 30, 2021	Sep. 30, 2020
Stock compensation
Stock compensation expense	$ 42.7	$ 43.8	$ 134.8	$ 132.6
Stock Compensation Expense Capitalized	0.6	0.2	$ 1.8	0.5
Assumed annualized forfeiture rate (as a percent)			5.00%
Weighted-average fair value assumptions
Valuation method			Black-Scholes valuation model
Research and Development Expense
Stock compensation
Stock compensation expense	26.3	29.0	$ 84.2	90.2
Selling, General and Administrative Expenses
Stock compensation
Stock compensation expense	15.9	14.6	49.5	41.7
Cost of product revenues
Stock compensation
Stock compensation expense	$ 0.5	$ 0.2	$ 1.1	$ 0.7
Stock Options
Weighted-average fair value assumptions
Average risk-free interest rates (as a percent)	0.76%	0.28%	0.60%	0.85%
Average expected life (in years)	5 years 1 month 28 days	5 years 1 month 24 days	5 years	4 years 11 months 15 days
Volatility (as a percent)	38.00%	39.00%	39.00%	40.00%
Weighted-average fair value (in dollars per share)	$ 28.84	$ 36.73	$ 29.32	$ 32.79
Unrecognized compensation
Unrecognized compensation cost for nonvested option (in dollars)	$ 77.3		$ 77.3
Vesting period of recognition of the unrecognized compensation cost of nonvested awards			1 year 3 months 18 days
Restricted Stock Units (RSUs)
Weighted-average fair value assumptions
Average risk-free interest rates (as a percent)	0.28%	0.13%	0.22%	0.17%
Average expected life (in years)	6 months	6 months	6 months	6 months
Volatility (as a percent)	25.00%	38.00%	31.00%	46.00%
Weighted-average fair value (in dollars per share)	$ 18.20	$ 22.83	$ 18.82	$ 19.07
Unrecognized compensation
Unrecognized compensation cost for nonvested option (in dollars)	$ 172.3		$ 172.3
Vesting period of recognition of the unrecognized compensation cost of nonvested awards			2 years
Performance Stock Units (PSUs)
Stock compensation
Stock compensation expense	1.7	$ 2.7	$ 5.0	$ 11.4
Unrecognized compensation
Unrecognized compensation cost for nonvested option (in dollars)	$ 19.2		$ 19.2
Vesting period of recognition of the unrecognized compensation cost of nonvested awards			1 year 7 months 6 days

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