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Accrued and Other Current Liabilities | 12 Months Ended
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Dec. 31, 2021
Accrued and Other Current Liabilities |
Accrued and Other Current Liabilities | Note 9. Accrued and Other Current Liabilities Accrued and other current liabilities consisted of the following (in thousands):
​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | December 31,
​ |  | 2021 |  | 2020
Royalties |  | $ | 168,412 | ​ | $ | 106,011
Clinical related costs | ​ | ​ | 109,486 |  |  | 115,897
Sales allowances | ​ | ​ | 136,541 | ​ | ​ | 73,204
Sales and marketing | ​ | ​ | 35,750 | ​ | ​ | 12,699
Construction in progress | ​ | ​ | 27,098 | ​ | ​ | 22,807
Operating lease liabilities | ​ | ​ | 10,554 | ​ | ​ | 12,674
Other current liabilities | ​ |  | 45,754 | ​ |  | 35,112
Total accrued and other current liabilities | ​ | $ | 533,595 | ​ | $ | 378,404
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