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License Agreements - Merus (Details) $ / shares in Units, $ in Thousands | 1 Months Ended | 12 Months Ended | 61 Months Ended
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Jan. 31, 2022 item | Jan. 31, 2021 USD ($) $ / shares shares | Jan. 31, 2017 USD ($) item | Dec. 31, 2016 USD ($) $ / shares shares | Dec. 31, 2021 USD ($) | Dec. 31, 2020 USD ($) | Dec. 31, 2019 USD ($) | Dec. 31, 2021 USD ($)
License agreements |  |  |  |  |  |  |  |
Long term investments |  |  |  |  | $ 221,266 | $ 222,301 |  | $ 221,266
Research and development expense |  |  |  |  | 1,458,179 | 2,215,942 | $ 1,154,111 |
Unrealized gain (loss) on long term investments |  |  |  |  | (24,072) | 10,426 | 34,458 |
Total revenues |  |  |  |  | 2,986,267 | 2,666,702 | 2,158,759 |
Net income (loss) |  |  |  |  | 948,581 | (295,697) | 446,906 |
Current assets |  |  |  |  | 3,118,674 | 2,359,894 |  | 3,118,674
Current liabilities |  |  |  |  | 854,308 | 631,195 |  | 854,308
Merus |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |
Number of independent programs | item |  |  | 10 |  |  |  |  |
Number of additional preclinical discovery programs | item | 10 |  |  |  |  |  |  |
Number of programs under the resulting products are co-funded for development | item | 2 |  |  |  |  |  |  |
Associated future global development costs , if elected to co-develop (as a percent) | 35.00% |  |  |  |  |  |  |
Milestone payment made under license agreement |  |  |  |  |  |  |  | 2,000
Merus | U.S. |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |
Profit sharing (as a percent) |  |  | 50.00% |  |  |  |  |
Percentage of profit (losses) |  |  | 50.00% |  |  |  |  |
Merus | Minimum |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  | 6.00% |  |  |  |  |
Merus | Minimum | U.S. |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  | 6.00% |  |  |  |  |
Merus | Maximum |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  | 10.00% |  |  |  |  |
Percentage of reverse royalty |  |  | 4.00% |  |  |  |  |
Merus | Maximum | U.S. |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  | 10.00% |  |  |  |  |
Percentage of additional royalties |  |  | 4.00% |  |  |  |  |
Merus | Maximum | Development and Regulatory Milestones |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |
Additional milestone payments under the license agreement |  |  | $ 100,000 |  |  |  |  |
Merus | Maximum | Commercialization Milestones |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |
Additional milestone payments under the license agreement |  |  | $ 250,000 |  |  |  |  |
Merus |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |
Fair market value of our long term investments |  |  |  |  | $ 112,900 | 56,100 |  | $ 112,900
Ownership percentage (as a percent) |  |  |  |  | 8.00% |  |  | 8.00%
Unrealized gain (loss) on long term investments |  |  |  |  | $ 48,100 | $ 11,000 | $ 300 |
Merus | IPO |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |
Common shares purchased (in shares) | shares |  | 350,000 |  |  |  |  |  |
Number of shares in underwritten public offering (in shares) | shares |  | 4,848,485 |  |  |  |  |  |
Per share price | $ / shares |  | $ 24.75 |  |  |  |  |  |
Value of shares acquired |  | $ 8,700 |  |  |  |  |  |
Merus | Stock purchase agreement |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |
Purchase of common stock under Stock Purchase Agreement (in shares ) | shares |  |  |  | 3,200,000 |  |  |  |
Purchase price of common stock |  |  |  | $ 80,000 |  |  |  |
Per share price | $ / shares |  |  |  | $ 25.00 |  |  |  |

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