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License Agreements - Calithera (Details) - USD ($) $ / shares in Units, $ in Thousands, shares in Millions | 1 Months Ended | 12 Months Ended |
--- | --- | --- | ---
Jan. 31, 2017 | Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2017 | Jan. 01, 2017
License agreements |  |  |  |  |  |
Long term investments |  | $ 221,266 | $ 222,301 |  |  |
Research and development expense |  | 1,458,179 | 2,215,942 | $ 1,154,111 |  |
Unrealized gain (loss) on long term investments |  | (24,072) | 10,426 | 34,458 |  |
Calithera |  |  |  |  |  |
License agreements |  |  |  |  |  |
Funding of future development costs (as a percent) | 70.00% |  |  |  |  |
Potential milestone payments to be made with profit sharing terminated | $ 720,000 |  |  |  |  |
Milestone payment made under license agreement |  |  |  |  | $ 12,000 |
Calithera | U.S. |  |  |  |  |  |
License agreements |  |  |  |  |  |
Percentage of profit (losses) | 60.00% |  |  |  |  |
Calithera |  |  |  |  |  |
License agreements |  |  |  |  |  |
Long term investments |  | $ 1,100 | 8,400 |  |  |
Ownership percentage (as a percent) |  | 2.00% |  |  |  |
Calithera | Other Comprehensive Income |  |  |  |  |  |
License agreements |  |  |  |  |  |
Unrealized gain (loss) on long term investments |  | $ (7,300) | $ (1,400) | $ 2,900 |  |
Calithera | Stock purchase agreement |  |  |  |  |  |
License agreements |  |  |  |  |  |
Purchase of common stock under Stock Purchase Agreement (in shares ) | 1.7 |  |  |  |  |
Purchase price of common stock |  |  |  |  |  | $ 8,000
Per share price |  |  |  |  |  | $ 4.65

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- Definition The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 912 -SubTopic 730 -Section 25 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6472174&loc=d3e58812-109433 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 985 -SubTopic 20 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6501960&loc=d3e128462-111756 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 730 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6420194&loc=d3e21568-108373 + Details
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