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Stock Compensation (Details) - USD ($) $ / shares in Units, $ in Millions | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Stock compensation |  |  |
Stock compensation expense | $ 183.0 | $ 177.9 | $ 166.6
Stock Compensation Expense Capitalized | $ 2.1 | 0.6 | 0.4
Weighted-average fair value assumptions |  |  |
Valuation method | Black-Scholes valuation model |  |
Dividend yield (as a percent) | 0.00% |  |
Research and Development Expense [Member] |  |  |
Stock compensation |  |  |
Stock compensation expense | $ 114.3 | 120.4 | 114.0
Selling, General and Administrative Expenses [Member] |  |  |
Stock compensation |  |  |
Stock compensation expense | 67.0 | 56.6 | 51.9
Cost of product revenues |  |  |
Stock compensation |  |  |
Stock compensation expense | 1.7 | 1.0 | 0.7
Employee Stock [Member] |  |  |
Stock compensation |  |  |
Stock compensation expense | $ 4.6 | $ 4.6 | $ 3.4
Weighted-average fair value assumptions |  |  |
Average risk-free interest rates (as a percent) | 0.40% | 0.17% | 1.82%
Average expected life (in years) | 6 months | 6 months | 6 months
Volatility (as a percent) | 33.00% | 45.00% | 31.00%
Weighted-average fair value (in dollars per share) | $ 18.02 | $ 19.13 | $ 14.04
Employee Stock Option |  |  |
Stock compensation |  |  |
Assumed annualized forfeiture rate (as a percent) | 5.00% |  |
Weighted-average fair value assumptions |  |  |
Average risk-free interest rates (as a percent) | 0.62% | 0.80% | 2.27%
Average expected life (in years) | 5 years 3 days | 4 years 11 months 23 days | 5 years 3 months 7 days
Volatility (as a percent) | 39.00% | 40.00% | 45.00%
Weighted-average fair value (in dollars per share) | $ 29.03 | $ 32.65 | $ 32.38
Unrecognized compensation |  |  |
Unrecognized compensation cost for nonvested option (in dollars) | $ 62.2 |  |
Vesting period of recognition of the unrecognized compensation cost of nonvested awards | 1 year 1 month 6 days |  |
Restricted Stock Units (RSUs) [Member] |  |  |
Stock compensation |  |  |
Assumed annualized forfeiture rate (as a percent) | 5.00% |  |
Unrecognized compensation |  |  |
Unrecognized compensation cost for nonvested option (in dollars) | $ 162.9 |  |
Vesting period of recognition of the unrecognized compensation cost of nonvested awards | 1 year 10 months 24 days |  |
Performance Stock Units (PSUs) |  |  |
Stock compensation |  |  |
Stock compensation expense | $ 8.3 | $ 13.9 | $ 9.9
Assumed annualized forfeiture rate (as a percent) | 5.00% |  |
Unrecognized compensation |  |  |
Unrecognized compensation cost for nonvested option (in dollars) | $ 24.3 |  |
Vesting period of recognition of the unrecognized compensation cost of nonvested awards | 1 year 10 months 24 days |  |

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