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License Agreements - Lilly (Details) - USD ($) $ in Thousands | 1 Months Ended | 12 Months Ended | 145 Months Ended |
--- | --- | --- | --- | ---
May 31, 2019 | Dec. 31, 2009 | Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2021 | Mar. 31, 2016
License agreements |  |  |  |  |  |  |
Research and Development Expense |  |  | $ 1,458,179 | $ 2,215,942 | $ 1,154,111 |  |
Revenues |  |  | 2,986,267 | 2,666,702 | 2,158,759 |  |
Europe |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |
Revenues |  |  | 124,100 | 105,000 | 90,000 |  |
Product royalty revenues |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |
Revenues |  |  | 569,255 | 392,966 | 306,337 |  |
Eli Lilly |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |
Revenues |  |  | 50,000 | 30,000 | 0 |  |
Eli Lilly | Non-U.S. |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |
Revenues |  |  | 220,900 | $ 110,900 | $ 80,400 |  |
Eli Lilly | Development Milestones |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  | $ 149,000 |
Eli Lilly | Development Milestones | Maximum |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  | $ 150,000 |  |  |  |  |
Eli Lilly | Regulatory Milestones |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  | 265,000 |
Eli Lilly | Regulatory Milestones | Japan |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  | 10,000 |  |  |  |
Eli Lilly | Regulatory Milestones | Europe |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  | 20,000 |  |  |  |
Eli Lilly | Regulatory Milestones | Maximum |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  | 365,000 |  |  |  |  |
Eli Lilly | Commercialization Milestones |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  | 50,000 |  |  | $ 50,000 |
Annual net sales of a licensed product for the achievement of a predefined milestone |  |  | $ 1,000,000 |  |  |  |
Eli Lilly | Commercialization Milestones | Maximum |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  | $ 150,000 |  |  |  |  |
Eli Lilly | GVHD |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |
Additional milestone payments under the license agreement |  |  |  |  |  |  | $ 40,000
Eli Lilly | GVHD | Regulatory Milestones |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |
Milestone payment made under license agreement | $ 20,000 |  |  |  |  |  |

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- Definition The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 912 -SubTopic 730 -Section 25 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6472174&loc=d3e58812-109433 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 985 -SubTopic 20 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6501960&loc=d3e128462-111756 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 730 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6420194&loc=d3e21568-108373 + Details
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