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License Agreements - Agenus (Details) $ / shares in Units, $ in Thousands, shares in Millions		1 Months Ended	12 Months Ended			84 Months Ended
	Feb. 01, 2017 USD ($) $ / shares shares	Jan. 31, 2015 item	Dec. 31, 2021 USD ($) shares	Dec. 31, 2020 USD ($) shares	Dec. 31, 2019 USD ($)	Dec. 31, 2021 USD ($)
License agreements
Long term investments			$ 221,266	$ 222,301		$ 221,266
Unrealized gain (loss) on long term investments			(24,072)	10,426	$ 34,458
Research and development expense			1,458,179	2,215,942	1,154,111
Agenus
License agreements
Long term investments			$ 38,900	$ 44,700		$ 38,900
Shares divested (in shares) | shares			2.0	3.7
Gross proceeds from sale of stock			$ 10,500	$ 17,200
Ownership percentage (as a percent)			5.00%			5.00%
Unrealized gain (loss) on long term investments			$ 4,600	$ (10,300)	$ 30,000
Stock purchase agreement | Agenus
License agreements
Purchase of common stock under Stock Purchase Agreement (in shares ) | shares	10.0
Purchase price of common stock	$ 60,000
Per share price | $ / shares	$ 6.00
Agenus
License agreements
Number of program targets | item		4
Royalty payments on future global net sales (as a percent)			15.00%
Milestone payment made under license agreement						$ 30,000
Agenus | Development, Regulatory and Commercialization Milestones
License agreements
Additional milestone payments under the license agreement			$ 500,000			$ 500,000
Agenus | Development, Regulatory and Commercialization Milestones | Minimum
License agreements
Royalty payments on future global net sales (as a percent)			6.00%
Agenus | Development, Regulatory and Commercialization Milestones | Maximum
License agreements
Royalty payments on future global net sales (as a percent)			12.00%

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Represents range of tiered, double-digit royalty payments on future global sales if product is successfully commercialized.

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Amount of unrealized gain (loss) on investment in equity security measured at fair value with change in fair value recognized in net income (FV-NI).

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The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

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