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License Agreements - Merus (Details) $ / shares in Units, $ in Thousands	1 Months Ended				12 Months Ended			61 Months Ended
	Jan. 31, 2022 item	Jan. 31, 2021 USD ($) $ / shares shares	Jan. 31, 2017 USD ($) item	Dec. 31, 2016 USD ($) $ / shares shares	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)	Dec. 31, 2019 USD ($)	Dec. 31, 2021 USD ($)
License agreements
Long term investments					$ 221,266	$ 222,301		$ 221,266
Research and development expense					1,458,179	2,215,942	$ 1,154,111
Unrealized gain (loss) on long term investments					(24,072)	10,426	34,458
Total revenues					2,986,267	2,666,702	2,158,759
Net income (loss)					948,581	(295,697)	446,906
Current assets					3,118,674	2,359,894		3,118,674
Current liabilities					854,308	631,195		854,308
Merus
License agreements
Number of independent programs | item			10
Number of additional preclinical discovery programs | item	10
Number of programs under the resulting products are co-funded for development | item	2
Associated future global development costs , if elected to co-develop (as a percent)	35.00%
Milestone payment made under license agreement								2,000
Merus | U.S.
License agreements
Profit sharing (as a percent)			50.00%
Percentage of profit (losses)			50.00%
Merus | Minimum
License agreements
Royalty payments on future global net sales (as a percent)			6.00%
Merus | Minimum | U.S.
License agreements
Royalty payments on future global net sales (as a percent)			6.00%
Merus | Maximum
License agreements
Royalty payments on future global net sales (as a percent)			10.00%
Percentage of reverse royalty			4.00%
Merus | Maximum | U.S.
License agreements
Royalty payments on future global net sales (as a percent)			10.00%
Percentage of additional royalties			4.00%
Merus | Maximum | Development and Regulatory Milestones
License agreements
Additional milestone payments under the license agreement			$ 100,000
Merus | Maximum | Commercialization Milestones
License agreements
Additional milestone payments under the license agreement			$ 250,000
Merus
License agreements
Fair market value of our long term investments					$ 112,900	56,100		$ 112,900
Ownership percentage (as a percent)					8.00%			8.00%
Unrealized gain (loss) on long term investments					$ 48,100	$ 11,000	$ 300
Merus | IPO
License agreements
Common shares purchased (in shares) | shares		350,000
Number of shares in underwritten public offering (in shares) | shares		4,848,485
Per share price | $ / shares		$ 24.75
Value of shares acquired		$ 8,700
Merus | Stock purchase agreement
License agreements
Purchase of common stock under Stock Purchase Agreement (in shares ) | shares				3,200,000
Purchase price of common stock				$ 80,000
Per share price | $ / shares				$ 25.00

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