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License Agreements - Calithera (Details) - USD ($)
$ / shares in Units, $ in Thousands, shares in Millions
1 Months Ended 12 Months Ended
Jan. 31, 2017
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2017
Jan. 01, 2017
License agreements            
Long term investments   $ 221,266 $ 222,301      
Research and development expense   1,458,179 2,215,942 $ 1,154,111    
Unrealized gain (loss) on long term investments   (24,072) 10,426 34,458    
Calithera            
License agreements            
Funding of future development costs (as a percent) 70.00%          
Potential milestone payments to be made with profit sharing terminated $ 720,000          
Milestone payment made under license agreement         $ 12,000  
Calithera | U.S.            
License agreements            
Percentage of profit (losses) 60.00%          
Calithera            
License agreements            
Long term investments   $ 1,100 8,400      
Ownership percentage (as a percent)   2.00%        
Calithera | Other Comprehensive Income            
License agreements            
Unrealized gain (loss) on long term investments   $ (7,300) $ (1,400) $ 2,900    
Calithera | Stock purchase agreement            
License agreements            
Purchase of common stock under Stock Purchase Agreement (in shares ) 1.7          
Purchase price of common stock           $ 8,000
Per share price           $ 4.65