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License Agreements - Innovent (Details) - Innovent $ in Millions	1 Months Ended		12 Months Ended
	Jan. 31, 2019 USD ($)	Dec. 31, 2018 USD ($)	Dec. 31, 2021 USD ($) item	Dec. 31, 2020 USD ($)	Dec. 31, 2019 USD ($)	Dec. 31, 2018 USD ($)
License agreements
Upfront and immediate milestone payment to be received under license agreement	$ 40.0
Product candidates | item			3
Development and Regulatory Milestones
License agreements
Amount recognized and received for the achievement of a predefined milestone					$ 20.0
Development and Regulatory Milestones | Maximum
License agreements
Upfront and immediate milestone payment to be received under license agreement		$ 94.0
Development and Regulatory Milestones | PEMAZYRE
License agreements
Amount recognized and received for the achievement of a predefined milestone			$ 10.0	$ 5.0
Commercialization Milestones | Maximum
License agreements
Upfront and immediate milestone payment to be received under license agreement						$ 202.5

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- Definition

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- Definition

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- Definition

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