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License Agreements - Syndax (Details) - USD ($) $ / shares in Units, $ in Thousands, shares in Millions		1 Months Ended	12 Months Ended
	Dec. 09, 2021	Sep. 30, 2021	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Long term investments			$ 221,266	$ 222,301
Research and Development Expense			1,458,179	2,215,942	$ 1,154,111
Unrealized (loss) gain on long term investments			(24,072)	$ 10,426	$ 34,458
Investment in Syndax
Purchase of common stock under Stock Purchase Agreement (in shares )		1.4
Equity Method Investment, Aggregate Cost	$ 35,000	$ 35,000
Per share price	$ 17.48	$ 24.62
Lock-up period		6 months
Long term investments	$ 24,800		$ 31,100
Research and Development Expense	$ 10,200
Ownership percentage (as a percent)			3.00%
Unrealized (loss) gain on long term investments			$ 6,300
Syndax
Upfront payment under license agreement		$ 117,000
Syndax | Development and Regulatory Milestones | Maximum
Additional milestone payments under the license agreement		220,000
Syndax | Commercialization Milestones | Maximum
Additional milestone payments under the license agreement		$ 230,000
Syndax | Syndax | U.S.
Funding of future development costs (as a percent)		45.00%
Syndax | Incyte | U.S.
Funding of future development costs (as a percent)		55.00%

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The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

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