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Stockholders' Equity - Stock options outstanding (Details)	12 Months Ended
	Dec. 31, 2021 $ / shares shares
Options Outstanding
Number Outstanding (in shares) | shares	12,763,460
Options Exercisable
Number Exercisable (in shares) | shares	8,024,951
Range of Exercise Prices $22.05 - $68.62
Stock options outstanding
Exercise price, lower range limit (in dollars per share)	$ 22.05
Exercise price, upper range limit (in dollars per share)	$ 68.62
Options Outstanding
Number Outstanding (in shares) | shares	1,304,595
Weighted Average Remaining Contractual Life	6 years 18 days
Weighted Average Exercise Price (in dollars per share)	$ 64.71
Options Exercisable
Number Exercisable (in shares) | shares	1,048,050
Weighted Average Exercise Price (in dollars per share)	$ 64.04
Range of Exercise Prices $68.82 - $69.35
Stock options outstanding
Exercise price, lower range limit (in dollars per share)	68.82
Exercise price, upper range limit (in dollars per share)	$ 69.35
Options Outstanding
Number Outstanding (in shares) | shares	89,030
Weighted Average Remaining Contractual Life	8 years 4 months 6 days
Weighted Average Exercise Price (in dollars per share)	$ 69.15
Options Exercisable
Number Exercisable (in shares) | shares	31,252
Weighted Average Exercise Price (in dollars per share)	$ 68.95
Range of Exercise Prices $72.27 - $72.27
Stock options outstanding
Exercise price, lower range limit (in dollars per share)	72.27
Exercise price, upper range limit (in dollars per share)	$ 72.27
Options Outstanding
Number Outstanding (in shares) | shares	1,470,150
Weighted Average Remaining Contractual Life	6 years 10 months 17 days
Weighted Average Exercise Price (in dollars per share)	$ 72.27
Options Exercisable
Number Exercisable (in shares) | shares	770,726
Weighted Average Exercise Price (in dollars per share)	$ 72.27
Range of Exercise Prices $72.58 - $80.50
Stock options outstanding
Exercise price, lower range limit (in dollars per share)	72.58
Exercise price, upper range limit (in dollars per share)	$ 80.50
Options Outstanding
Number Outstanding (in shares) | shares	1,614,398
Weighted Average Remaining Contractual Life	5 years 9 months 7 days
Weighted Average Exercise Price (in dollars per share)	$ 77.49
Options Exercisable
Number Exercisable (in shares) | shares	1,131,015
Weighted Average Exercise Price (in dollars per share)	$ 76.77
Range of Exercise Prices $80.56 - $83.58
Stock options outstanding
Exercise price, lower range limit (in dollars per share)	80.56
Exercise price, upper range limit (in dollars per share)	$ 83.58
Options Outstanding
Number Outstanding (in shares) | shares	1,338,974
Weighted Average Remaining Contractual Life	9 years 3 months 3 days
Weighted Average Exercise Price (in dollars per share)	$ 83.34
Options Exercisable
Number Exercisable (in shares) | shares	72,885
Weighted Average Exercise Price (in dollars per share)	$ 81.68
Range of Exercise Prices $83.83 - $85.01
Stock options outstanding
Exercise price, lower range limit (in dollars per share)	83.83
Exercise price, upper range limit (in dollars per share)	$ 85.01
Options Outstanding
Number Outstanding (in shares) | shares	1,371,805
Weighted Average Remaining Contractual Life	6 years 1 month 20 days
Weighted Average Exercise Price (in dollars per share)	$ 84.52
Options Exercisable
Number Exercisable (in shares) | shares	1,008,722
Weighted Average Exercise Price (in dollars per share)	$ 84.42
Range of Exercise Prices $85.34 - $94.63
Stock options outstanding
Exercise price, lower range limit (in dollars per share)	85.34
Exercise price, upper range limit (in dollars per share)	$ 94.63
Options Outstanding
Number Outstanding (in shares) | shares	1,655,056
Weighted Average Remaining Contractual Life	7 years 7 months 17 days
Weighted Average Exercise Price (in dollars per share)	$ 91.18
Options Exercisable
Number Exercisable (in shares) | shares	927,332
Weighted Average Exercise Price (in dollars per share)	$ 92.12
Range of Exercise Prices $95.34 - $101.79
Stock options outstanding
Exercise price, lower range limit (in dollars per share)	95.34
Exercise price, upper range limit (in dollars per share)	$ 101.79
Options Outstanding
Number Outstanding (in shares) | shares	1,293,897
Weighted Average Remaining Contractual Life	3 years 10 months 17 days
Weighted Average Exercise Price (in dollars per share)	$ 96.28
Options Exercisable
Number Exercisable (in shares) | shares	876,609
Weighted Average Exercise Price (in dollars per share)	$ 96.33
Range of Exercise Prices $102.65 - $113.64
Stock options outstanding
Exercise price, lower range limit (in dollars per share)	102.65
Exercise price, upper range limit (in dollars per share)	$ 113.64
Options Outstanding
Number Outstanding (in shares) | shares	1,853,430
Weighted Average Remaining Contractual Life	6 years 1 month 9 days
Weighted Average Exercise Price (in dollars per share)	$ 109.99
Options Exercisable
Number Exercisable (in shares) | shares	1,386,235
Weighted Average Exercise Price (in dollars per share)	$ 111.21
Range of Exercise Prices $115.19 - $138.52
Stock options outstanding
Exercise price, lower range limit (in dollars per share)	115.19
Exercise price, upper range limit (in dollars per share)	$ 138.52
Options Outstanding
Number Outstanding (in shares) | shares	772,125
Weighted Average Remaining Contractual Life	4 years 11 months 4 days
Weighted Average Exercise Price (in dollars per share)	$ 128.71
Options Exercisable
Number Exercisable (in shares) | shares	772,125
Weighted Average Exercise Price (in dollars per share)	$ 128.71

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