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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Cash flows from operating activities:      
Net income (loss) $ 948,581 $ (295,697) $ 446,906
Adjustments to reconcile net income to net cash provided by operating activities:      
Depreciation and amortization 57,844 51,807 54,533
Stock-based compensation 183,006 177,877 166,589
Deferred income taxes (including benefit from valuation allowance release) (465,604) (350) (377)
Other, net 1,417 546 486
Unrealized loss (gain) on long term investments 24,072 (10,426) (34,458)
Change in fair value of acquisition-related contingent consideration 14,741 23,385 19,682
Changes in operating assets and liabilities:      
Accounts receivable (134,306) (173,185) (1,211)
Prepaid expenses and other assets (64,080) (8,050) 5,744
Inventory (20,965) (19,468) (6,100)
Accounts payable 73,343 15,120 (20,180)
Accrued and other liabilities 131,439 113,842 79,042
Net cash provided by (used in) operating activities 749,488 (124,599) 710,656
Cash flows from investing activities:      
Purchase of long term investments (33,510) (95,468)  
Sale of long term investments 10,473 17,250  
Capital expenditures (181,006) (187,379) (78,064)
Purchases of marketable securities (235,167) (516,874) (374,809)
Sale and maturities of marketable securities 231,511 513,470 365,419
Net cash used in investing activities (207,699) (269,001) (87,454)
Cash flows from financing activities:      
Proceeds from issuance of common stock under stock plans 58,626 133,064 80,050
Tax withholdings related to restricted and performance share vesting (29,940) (22,759) (16,751)
Payment of finance lease liabilities (2,417) (836) (822)
Payment of contingent consideration (20,093) (37,760) (16,766)
Net cash provided by financing activities 6,176 71,709 45,711
Effect of exchange rates on cash, cash equivalents, restricted cash and investments (3,570) 2,949 (192)
Net increase (decrease) in cash, cash equivalents, restricted cash and investments 544,395 (318,942) 668,721
Cash, cash equivalents, restricted cash and investments at beginning of period 1,514,765 1,833,707 1,164,986
Cash, cash equivalents, restricted cash and investments at end of period 2,059,160 1,514,765 1,833,707
Supplemental Schedule of Cash Flow Information      
Interest paid 396 194 239
Income taxes paid 67,731 70,712 33,553
Unpaid purchases of property and equipment 27,098 22,807 12,732
Leased assets obtained in exchange for new operating lease liabilities 14,416 19,908 7,607
Leased assets obtained in exchange for new finance lease liabilities $ 1,513 2,160 $ 29,889
Convertible Senior Notes 1.25 Percent Due 2020      
Supplemental Schedule of Cash Flow Information      
Reclassification to common stock and additional paid in capital in connection with conversion/exchange of debt instruments   $ 18,999