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License Agreements - Calithera (Details) - USD ($)
$ / shares in Units, $ in Thousands, shares in Millions
1 Months Ended 3 Months Ended 12 Months Ended 63 Months Ended
Jan. 31, 2017
Mar. 31, 2022
Mar. 31, 2021
Dec. 31, 2017
Mar. 31, 2022
Dec. 31, 2021
License agreements            
Long term investments   $ 174,681     $ 174,681 $ 221,266 [1]
Research and development expense   353,373 $ 306,896      
Unrealized gain (loss) on long term investments   (46,585) (27,709)      
Calithera            
License agreements            
Fair market value of our long term investments   $ 700     $ 700 $ 1,100
Ownership percentage (as a percent)   2.00%     2.00%  
Unrealized gain (loss) on long term investments   $ (500) $ (4,300)      
Calithera            
License agreements            
Funding of future development costs (as a percent) 70.00%          
Milestone payment made under license agreement         $ 12,000  
Calithera | Maximum | Development, Regulatory and Commercialization Milestones            
License agreements            
Potential milestone payments to be made with profit sharing terminated $ 720,000          
Calithera | U.S.            
License agreements            
Percentage of profit (losses) 60.00%          
Stock purchase agreement | Calithera            
License agreements            
Purchase of common stock under Stock Purchase Agreement (in shares )       1.7    
Purchase price of common stock       $ 8,000    
Per share price       $ 4.65    
[1] The condensed consolidated balance sheet at December 31, 2021 has been derived from the audited consolidated financial statements at that date.