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Stock Compensation (Details) - USD ($)
$ / shares in Units, $ in Millions
3 Months Ended
Mar. 31, 2022
Mar. 31, 2021
Stock compensation    
Stock compensation expense $ 43.8 $ 47.3
Assumed annualized forfeiture rate (as a percent) 5.00%  
Weighted-average fair value assumptions    
Valuation method Black-Scholes valuation model  
Dividend yield (as a percent) 0.00%  
Research and Development Expense [Member]    
Stock compensation    
Stock compensation expense $ 26.3 29.9
Selling, General and Administrative Expenses [Member]    
Stock compensation    
Stock compensation expense 16.9 17.2
Cost of product revenues    
Stock compensation    
Stock compensation expense $ 0.6 $ 0.2
Employee Stock [Member]    
Weighted-average fair value assumptions    
Average risk-free interest rates (as a percent) 2.28% 0.16%
Average expected life (in years) 2 months 26 days 3 months
Volatility (as a percent) 24.00% 39.00%
Weighted-average fair value (in dollars per share) $ 13.76 $ 19.08
Employee Stock Option    
Weighted-average fair value assumptions    
Average risk-free interest rates (as a percent) 1.47% 0.34%
Average expected life (in years) 4 years 7 months 28 days 4 years 8 months 4 days
Volatility (as a percent) 38.00% 39.00%
Weighted-average fair value (in dollars per share) $ 25.15 $ 29.88
Unrecognized compensation    
Unrecognized compensation cost for nonvested option (in dollars) $ 68.0  
Vesting period of recognition of the unrecognized compensation cost of nonvested awards 1 year 2 months 12 days  
Restricted Stock Units (RSUs)    
Unrecognized compensation    
Unrecognized compensation cost for nonvested option (in dollars) $ 153.8  
Vesting period of recognition of the unrecognized compensation cost of nonvested awards 1 year 10 months 24 days  
Performance Stock Units (PSUs)    
Stock compensation    
Stock compensation expense $ 1.8 $ 2.6
Unrecognized compensation    
Unrecognized compensation cost for nonvested option (in dollars) $ 25.1  
Vesting period of recognition of the unrecognized compensation cost of nonvested awards 1 year 7 months 6 days