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Accrued and Other Current Liabilities (Tables) | 6 Months Ended
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Jun. 30, 2022
Accrued and Other Current Liabilities |
Schedule of accrued and other current liabilities | Accrued and other current liabilities consisted of the following (in thousands):
​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | June 30, | ​ | December 31,
​ |  | 2022 |  | 2021
Royalties |  | $ | 209,501 | ​ | $ | 168,412
Clinical related costs | ​ | ​ | 137,445 |  |  | 109,486
Sales allowances | ​ | ​ | 141,538 | ​ | ​ | 136,541
Sales and marketing | ​ | ​ | 34,607 | ​ | ​ | 35,750
Construction in progress | ​ | ​ | 8,952 | ​ | ​ | 27,098
Operating lease liabilities | ​ | ​ | 9,369 | ​ | ​ | 10,554
Other current liabilities | ​ |  | 57,396 | ​ |  | 45,754
Total accrued and other current liabilities | ​ | $ | 598,808 | ​ | $ | 533,595
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