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License Agreements - Syndax (Details) - USD ($) $ / shares in Units, $ in Thousands, shares in Millions |  | 1 Months Ended | 3 Months Ended | 6 Months Ended
--- | --- | --- | --- | ---
Dec. 09, 2021 | Dec. 31, 2021 | Sep. 30, 2021 | Jun. 30, 2022 | Jun. 30, 2021 | Jun. 30, 2022 | Jun. 30, 2021
Long term investments |  | $ 221,266 |  | $ 149,784 |  | $ 149,784 |
Research and Development Expense |  |  |  | 347,196 | $ 343,511 | 700,569 | $ 650,407
Unrealized gain (loss) on long term investments |  |  |  | (24,897) | $ 26,765 | (71,482) | $ (944)
Investment in Syndax |  |  |  |  |  |  |
Long term investments |  | 31,100 |  | $ 27,400 |  | $ 27,400 |
Ownership percentage (as a percent) |  |  |  | 3.00% |  | 3.00% |
Unrealized gain (loss) on long term investments |  |  |  | $ 2,700 |  | $ (3,800) |
Syndax |  |  |  |  |  |  |
Upfront payment under license agreement |  | $ 117,000 |  |  |  |  |
Syndax | Development and Regulatory Milestones | Maximum |  |  |  |  |  |  |
Additional milestone payments under the license agreement |  |  | $ 220,000 |  |  |  |
Syndax | Commercialization Milestones | Maximum |  |  |  |  |  |  |
Additional milestone payments under the license agreement |  |  | $ 230,000 |  |  |  |
Syndax | Syndax | U.S. |  |  |  |  |  |  |
Funding of future development costs (as a percent) |  |  | 45.00% |  |  |  |
Syndax | Incyte | U.S. |  |  |  |  |  |  |
Funding of future development costs (as a percent) |  |  | 55.00% |  |  |  |
Stock purchase agreement | Investment in Syndax |  |  |  |  |  |  |
Purchase of common stock under Stock Purchase Agreement (in shares ) |  |  | 1.4 |  |  |  |
Purchase price of common stock | $ 35,000 |  | $ 35,000 |  |  |  |
Per share price | $ 17.48 |  | $ 24.62 |  |  |  |
Long term investments | $ 24,800 |  |  |  |  |  |
Research and Development Expense | $ 10,200 |  |  |  |  |  |

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