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License Agreements - Syndax (Details) - USD ($) $ / shares in Units, $ in Thousands, shares in Millions		1 Months Ended		3 Months Ended		6 Months Ended
	Dec. 09, 2021	Dec. 31, 2021	Sep. 30, 2021	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Long term investments		$ 221,266		$ 149,784		$ 149,784
Research and Development Expense				347,196	$ 343,511	700,569	$ 650,407
Unrealized gain (loss) on long term investments				(24,897)	$ 26,765	(71,482)	$ (944)
Investment in Syndax
Long term investments		31,100		$ 27,400		$ 27,400
Ownership percentage (as a percent)				3.00%		3.00%
Unrealized gain (loss) on long term investments				$ 2,700		$ (3,800)
Syndax
Upfront payment under license agreement		$ 117,000
Syndax | Development and Regulatory Milestones | Maximum
Additional milestone payments under the license agreement			$ 220,000
Syndax | Commercialization Milestones | Maximum
Additional milestone payments under the license agreement			$ 230,000
Syndax | Syndax | U.S.
Funding of future development costs (as a percent)			45.00%
Syndax | Incyte | U.S.
Funding of future development costs (as a percent)			55.00%
Stock purchase agreement | Investment in Syndax
Purchase of common stock under Stock Purchase Agreement (in shares )			1.4
Purchase price of common stock	$ 35,000		$ 35,000
Per share price	$ 17.48		$ 24.62
Long term investments	$ 24,800
Research and Development Expense	$ 10,200

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