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License Agreements - Novartis (Details) - USD ($) $ in Thousands | 1 Months Ended | 3 Months Ended | 9 Months Ended | 155 Months Ended |
--- | --- | --- | --- | --- | ---
May 31, 2022 | Apr. 30, 2022 | Nov. 30, 2009 | Sep. 30, 2022 | Sep. 30, 2021 | Sep. 30, 2022 | Sep. 30, 2021 | Sep. 30, 2022 | Dec. 31, 2021
License Agreements |  |  |  |  |  |  |  |  |
Revenues |  |  |  | $ 823,303 | $ 812,987 | $ 2,467,935 | $ 2,123,414 |  |
Product royalty revenues |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Revenues |  |  |  | 110,293 | 183,974 | 350,253 | 404,440 |  |
JAKAFI |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Revenues |  |  |  | 619,595 | 547,373 | 1,761,732 | 1,542,138 |  |
Milestone and contract revenues |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Revenues |  |  |  | 0 | 35,000 | 135,000 | 45,000 |  |
Novartis |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Royalties payable |  |  |  | 221,700 |  | $ 221,700 |  | $ 221,700 | $ 148,100
Novartis | JAKAVI | Minimum |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  |  |  |  | 12.00% |  |  |
Novartis | JAKAVI | Maximum |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  |  |  |  | 14.00% |  |  |
Novartis | JAKAFI | UNITED STATES |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Royalties payable on net sales |  |  |  | 30,300 | 26,900 | $ 81,300 | 70,600 |  |
Novartis | JAKAFI | Non-US |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Royalties payable on net sales |  |  |  | 85,800 | 94,700 | 240,400 | 242,300 |  |
Novartis | Milestone and contract revenues |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Revenues |  |  |  | 0 |  | 60,000 |  |  |
Novartis | TABRECTA PROD SERV | Non-US |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Royalties payable on net sales |  |  |  | $ 4,100 | $ 2,700 | 11,200 | $ 7,300 |  |
Novartis | Development Milestones |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  | 157,000 |
Novartis | Development Milestones | Maximum |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  | $ 174,000 |  |  |  |  |  |
Novartis | Regulatory Milestones |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  | 340,000 |
Novartis | Regulatory Milestones | Maximum |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  | 495,000 |  |  |  |  |  |
Novartis | Regulatory Milestones | TABRECTA |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  | $ 15,000 |  |  |  |  |  |  |
Novartis | Regulatory Milestones | JAKAVI |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone | $ 45,000 |  |  |  |  |  |  |  |
Novartis | Commercialization Milestones |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  | $ 200,000 |
Novartis | Commercialization Milestones | Maximum |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  | $ 500,000 |  |  |  |  |  |
Novartis | Development and Regulatory Milestones | Maximum |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  |  |  |  | $ 75,000 |  |  |

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