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License Agreements - Agenus (Details) - USD ($) $ / shares in Units, $ in Thousands, shares in Millions | 1 Months Ended | 3 Months Ended | 9 Months Ended | 12 Months Ended | 93 Months Ended
--- | --- | --- | --- | --- | ---
Feb. 28, 2017 | Sep. 30, 2022 | Sep. 30, 2021 | Sep. 30, 2022 | Sep. 30, 2021 | Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2017 | Sep. 30, 2022
License Agreements |  |  |  |  |  |  |  |  |
Fair market long term investments |  | $ 149,124 |  | $ 149,124 |  | $ 221,266 |  |  | $ 149,124
Unrealized gain (loss) on long term investments |  | (660) | $ (27,450) | (72,142) | $ (28,394) |  |  |  |
Agenus |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Shares divested (in shares) |  |  |  |  |  | 2.0 | 3.7 |  |
Gross proceeds from sale of stock |  |  |  |  |  | $ 10,500 | $ 17,200 |  |
Fair market long term investments |  | 24,800 |  | 24,800 |  | $ 38,900 |  |  | 24,800
Unrealized gain (loss) on long term investments |  | 1,300 | $ (2,800) | (14,100) | $ 29,100 |  |  |  |
Royalty-bearing product GITR, OX40 and one undisclosed target | Agenus | Maximum |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) | 15.00% |  |  |  |  |  |  |  |
Agenus |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Period of notice for termination of license agreement | 12 months |  |  |  |  |  |  |  |
Agenus | Royalty-bearing product other than GITR, OX40 and one undisclosed target | Minimum |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) | 6.00% |  |  |  |  |  |  |  |
Agenus | Royalty-bearing product other than GITR, OX40 and one undisclosed target | Maximum |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) | 12.00% |  |  |  |  |  |  |  |
Agenus | Development, Regulatory and Commercialization Milestones |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Milestone payment made under license agreement |  |  |  |  |  |  |  |  | 30,000
Additional milestone payments under the license agreement |  | $ 500,000 |  | $ 500,000 |  |  |  |  | $ 500,000
Stock purchase agreement | Agenus |  |  |  |  |  |  |  |  |
License Agreements |  |  |  |  |  |  |  |  |
Purchase of common stock under Stock Purchase Agreement (in shares ) |  |  |  |  |  |  |  | 10.0 |
Purchase price of common stock |  |  |  |  |  |  |  | $ 60,000 |
Per share price (In USD per share) |  |  |  |  |  |  |  | $ 6.00 |

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