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CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2022
Sep. 30, 2021
Sep. 30, 2022
Sep. 30, 2021
Revenues:        
Total revenues $ 823,303 $ 812,987 $ 2,467,935 $ 2,123,414
Costs and expenses:        
Cost of product revenues (including definite-lived intangible amortization) 54,584 39,869 147,834 107,117
Research and development 384,007 334,945 1,084,576 985,352
Selling, general and administrative 266,460 190,704 729,321 513,358
(Gain) loss on change in fair value of acquisition-related contingent consideration (21,893) 2,910 (12,198) 13,068
Collaboration loss sharing 1,769 9,149 9,055 29,476
Total costs and expenses 684,927 577,577 1,958,588 1,648,371
Income from operations 138,376 235,410 509,347 475,043
Other income (expense), net 11,513 1,948 13,295 4,931
Interest expense (641) (439) (1,999) (1,156)
Unrealized loss on long term investments (660) (27,450) (72,142) (28,394)
Income before provision for income taxes 148,588 209,469 448,501 450,424
Provision for income taxes 35,813 27,730 136,302 65,694
Net income $ 112,775 $ 181,739 $ 312,199 $ 384,730
Net income per share:        
Basic (in USD per share) $ 0.51 $ 0.82 $ 1.41 $ 1.75
Diluted (in USD per share) $ 0.50 $ 0.82 $ 1.40 $ 1.73
Shares used in computing net income per share:        
Basic (in shares) 222,415 220,845 221,801 220,243
Diluted (in shares) 224,175 222,248 223,626 222,113
Product revenues, net        
Revenues:        
Total revenues $ 713,010 $ 594,013 $ 1,982,682 $ 1,673,974
Product royalty revenues        
Revenues:        
Total revenues 110,293 183,974 350,253 404,440
Milestone and contract revenues        
Revenues:        
Total revenues $ 0 $ 35,000 $ 135,000 $ 45,000