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License Agreements - Agenus (Details) - USD ($) $ / shares in Units, $ in Thousands, shares in Millions	1 Months Ended	3 Months Ended		9 Months Ended		12 Months Ended			93 Months Ended
	Feb. 28, 2017	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2017	Sep. 30, 2022
License Agreements
Fair market long term investments		$ 149,124		$ 149,124		$ 221,266			$ 149,124
Unrealized gain (loss) on long term investments		(660)	$ (27,450)	(72,142)	$ (28,394)
Agenus
License Agreements
Shares divested (in shares)						2.0	3.7
Gross proceeds from sale of stock						$ 10,500	$ 17,200
Fair market long term investments		24,800		24,800		$ 38,900			24,800
Unrealized gain (loss) on long term investments		1,300	$ (2,800)	(14,100)	$ 29,100
Royalty-bearing product GITR, OX40 and one undisclosed target | Agenus | Maximum
License Agreements
Royalty payments on future global net sales (as a percent)	15.00%
Agenus
License Agreements
Period of notice for termination of license agreement	12 months
Agenus | Royalty-bearing product other than GITR, OX40 and one undisclosed target | Minimum
License Agreements
Royalty payments on future global net sales (as a percent)	6.00%
Agenus | Royalty-bearing product other than GITR, OX40 and one undisclosed target | Maximum
License Agreements
Royalty payments on future global net sales (as a percent)	12.00%
Agenus | Development, Regulatory and Commercialization Milestones
License Agreements
Milestone payment made under license agreement									30,000
Additional milestone payments under the license agreement		$ 500,000		$ 500,000					$ 500,000
Stock purchase agreement | Agenus
License Agreements
Purchase of common stock under Stock Purchase Agreement (in shares )								10.0
Purchase price of common stock								$ 60,000
Per share price (In USD per share)								$ 6.00

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- Definition

Represents the additional milestone payments to be made under the license agreement.

+ References

No definition available.

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- Definition

Represents the amount of the milestone payment made under the license agreement.

+ References

No definition available.

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- Definition

Represents the notice period for the termination of license agreement.

+ References

No definition available.

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- Definition

Represents range of tiered, double-digit royalty payments on future global sales if product is successfully commercialized.

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- Definition

Represents the purchase of common stock under Stock Purchase Agreement.

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No definition available.

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- Definition

This element represents the aggregate cost of investments accounted for under the equity method of accounting.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
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-Name Accounting Standards Codification
-Topic 210
-SubTopic 10
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- Definition

Amount of unrealized gain (loss) on investment in equity security measured at fair value with change in fair value recognized in net income (FV-NI).

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 944
-SubTopic 220
-Section S99
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- Definition

The total amount of investments that are intended to be held for an extended period of time (longer than one operating cycle).

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-Name Accounting Standards Codification
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- Definition

Cash received on stock transaction after deduction of issuance costs.

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- Definition

The number of shares issued or sold by the subsidiary or equity method investee per stock transaction.

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- Definition

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