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License Agreements - Syndax (Details) - USD ($) $ / shares in Units, $ in Thousands, shares in Millions		1 Months Ended		3 Months Ended		9 Months Ended
	Dec. 09, 2021	Dec. 31, 2021	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
License Agreements
Fair market long term investments		$ 221,266		$ 149,124		$ 149,124
Research and development				384,007	$ 334,945	1,084,576	$ 985,352
Unrealized gain (loss) on long term investments				(660)	$ (27,450)	(72,142)	$ (28,394)
Investment in Syndax
License Agreements
Fair market long term investments		31,100		34,200		34,200
Unrealized gain (loss) on long term investments				6,800		3,100
Syndax
License Agreements
Upfront payment under license agreement		$ 117,000
Syndax | Development and Regulatory Milestones | Maximum
License Agreements
Additional milestone payments under the license agreement				220,000		220,000
Syndax | Commercialization Milestones | Maximum
License Agreements
Additional milestone payments under the license agreement				230,000		230,000
Syndax | Syndax | UNITED STATES
License Agreements
Funding of future development costs (as a percent)			45.00%
Syndax | Incyte | UNITED STATES
License Agreements
Funding of future development costs (as a percent)			55.00%
Stock purchase agreement | Investment in Syndax
License Agreements
Purchase of common stock under Stock Purchase Agreement (in shares )			1.4
Purchase price of common stock	$ 35,000			$ 35,000		$ 35,000
Per share price (In USD per share)	$ 17.48		$ 24.62		$ 24.62		$ 24.62
Fair market long term investments	$ 24,800
Research and development	$ 10,200

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The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

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