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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2022
Sep. 30, 2021
Cash flows from operating activities:    
Net income $ 312,199 $ 384,730
Adjustments to reconcile net income to net cash provided by operating activities:    
Depreciation and amortization 49,637 42,986
Stock-based compensation 135,741 134,784
Deferred income taxes 40,432 (178)
Other, net 15,097 5,268
Unrealized loss on long term investments 72,142 28,394
(Gain) loss on change in fair value of acquisition-related contingent consideration (12,198) 13,068
Changes in operating assets and liabilities:    
Accounts receivable (1,888) (34,695)
Prepaid expenses and other assets (40,016) (24,784)
Inventory (48,316) (16,215)
Accounts payable (8,935) 15,742
Accrued and other liabilities 172,384 85,037
Net cash provided by operating activities 686,279 634,137
Cash flows from investing activities:    
Purchase of long term investments 0 (8,662)
Sale of long term investments 0 10,473
Capital expenditures (56,560) (146,543)
Purchases of marketable securities (59,058) (228,170)
Sale and maturities of marketable securities 57,988 231,250
Net cash used in investing activities (57,630) (141,652)
Cash flows from financing activities:    
Proceeds from issuance of common stock under stock plans 42,989 48,432
Tax withholdings related to restricted and performance share vesting (25,724) (29,380)
Payment of finance lease liabilities (2,106) (1,788)
Payment of contingent consideration (13,473) (20,093)
Net cash provided by (used in) financing activities 1,686 (2,829)
Effect of exchange rates on cash, cash equivalents, restricted cash and investments 2,728 (3,718)
Net increase in cash, cash equivalents, restricted cash and investments 633,063 485,938
Cash, cash equivalents, restricted cash and investments at beginning of period 2,059,160 1,514,765
Cash, cash equivalents, restricted cash and investments at end of period 2,692,223 2,000,703
Supplemental Schedule of Cash Flow Information    
Income taxes paid 116,537 45,872
Unpaid purchases of property and equipment 8,836 23,892
Leased assets obtained in exchange for new operating lease liabilities 3,650 9,068
Leased assets obtained in exchange for new finance lease liabilities $ 1,448 $ 455