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License Agreements - Agenus (Details) $ / shares in Units, $ in Thousands, shares in Millions |  | 1 Months Ended | 12 Months Ended | 84 Months Ended
--- | --- | --- | --- | ---
Feb. 01, 2017 USD ($) $ / shares shares | Feb. 28, 2017 programTarget checkpointModulator | Dec. 31, 2022 USD ($) shares | Dec. 31, 2021 USD ($) shares | Dec. 31, 2020 USD ($) $ / shares | Dec. 31, 2021 USD ($)
License agreements |  |  |  |  |  |
Purchase price of common stock |  |  |  |  | $ 150,000 |
Per share price (in dollars per share) | $ / shares |  |  |  |  | $ 41.33 |
Long term investments |  |  | $ 133,676 | $ 221,266 |  | $ 221,266
Unrealized gain (loss) on long term investments |  |  | $ (87,590) | $ (24,072) | $ 10,426 |
Agenus |  |  |  |  |  |
License agreements |  |  |  |  |  |
Shares divested (in shares) | shares |  |  | 2.0 | 3.7 |  |
Gross proceeds from sale of stock |  |  | $ 10,500 | $ 17,200 |  |
Long term investments |  |  | 29,000 | 38,900 |  | 38,900
Unrealized gain (loss) on long term investments |  |  | $ (9,900) | $ 4,600 | $ (10,300) |
Agenus |  |  |  |  |  |
License agreements |  |  |  |  |  |
Number of checkpoint modulators | checkpointModulator |  | 4 |  |  |  |
Royalty payments on future global net sales |  |  | 15.00% |  |  |
License agreement, termination period |  |  | 12 months |  |  |
Milestone payment made under license agreement |  |  |  |  |  | $ 30,000
Agenus | Designated Target, Profit Share |  |  |  |  |  |
License agreements |  |  |  |  |  |
Number of program targets | programTarget |  | 2 |  |  |  |
Agenus | Designated Target, Tiered Royalties |  |  |  |  |  |
License agreements |  |  |  |  |  |
Number of program targets | programTarget |  | 1 |  |  |  |
Agenus | Designated Target, Royalties On Global Net Sales |  |  |  |  |  |
License agreements |  |  |  |  |  |
Number of program targets | programTarget |  | 1 |  |  |  |
Agenus | Development, Regulatory and Commercialization Milestones |  |  |  |  |  |
License agreements |  |  |  |  |  |
Additional milestone payments under the license agreement |  |  | $ 500,000 |  |  |
Agenus | Development, Regulatory and Commercialization Milestones | Minimum |  |  |  |  |  |
License agreements |  |  |  |  |  |
Royalty payments on future global net sales |  |  | 6.00% |  |  |
Agenus | Development, Regulatory and Commercialization Milestones | Maximum |  |  |  |  |  |
License agreements |  |  |  |  |  |
Royalty payments on future global net sales |  |  | 12.00% |  |  |
Stock purchase agreement | Agenus |  |  |  |  |  |
License agreements |  |  |  |  |  |
Purchase of common stock under Stock Purchase Agreement (in shares ) | shares | 10.0 |  |  |  |  |
Purchase price of common stock | $ 60,000 |  |  |  |  |
Per share price (in dollars per share) | $ / shares | $ 6.00 |  |  |  |  |

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