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License Agreements - Merus (Details) $ / shares in Units, $ in Thousands | 1 Months Ended | 12 Months Ended | 61 Months Ended |
--- | --- | --- | --- | ---
Jan. 31, 2022 program | Jan. 31, 2021 USD ($) $ / shares shares | Jan. 31, 2017 USD ($) program | Dec. 31, 2016 shares | Dec. 31, 2022 USD ($) | Dec. 31, 2021 USD ($) | Dec. 31, 2020 USD ($) $ / shares | Dec. 31, 2021 USD ($) | Dec. 31, 2017 USD ($) $ / shares
License agreements |  |  |  |  |  |  |  |  |
Purchase price of common stock |  |  |  |  |  |  | $ 150,000 |  |
Per share price (in dollars per share) | $ / shares |  |  |  |  |  |  | $ 41.33 |  |
Unrealized gain (loss) on long term investments |  |  |  |  | $ (87,590) | $ (24,072) | $ 10,426 |  |
Merus |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |
Fair market value of our long term investments |  |  |  |  | $ 54,900 | 112,900 |  | $ 112,900 |
Ownership percentage |  |  |  |  | 8.00% |  |  |  |
Unrealized gain (loss) on long term investments |  |  |  |  | $ (58,000) | $ 48,100 | $ 11,000 |  |
IPO | Merus |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |
Per share price (in dollars per share) | $ / shares |  | $ 24.75 |  |  |  |  |  |  |
Common shares purchased (in shares) | shares |  | 350,000 |  |  |  |  |  |  |
Number of shares in underwritten public offering (in shares) | shares |  | 4,848,485 |  |  |  |  |  |  |
Value of shares acquired |  | $ 8,700 |  |  |  |  |  |  |
Merus |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |
Number of independent programs | program |  |  | 10 |  |  |  |  |  |
Number of additional preclinical discovery programs | program | 10 |  |  |  |  |  |  |  |
Number of programs under the resulting products are co-funded for development | program | 2 |  |  |  |  |  |  |  |
Associated future global development costs , if elected to co-develop | 35.00% |  |  |  |  |  |  |  |
Number of projects with participation rights | program | 1 |  |  |  |  |  |  |  |
Milestone payment made under license agreement |  |  |  |  |  |  |  | $ 3,000 |
Number of programs terminated, reversal of royalties | program | 1 |  |  |  |  |  |  |  |
Merus | United States |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |
Profit sharing |  |  | 50.00% |  |  |  |  |  |
Percentage of profit (losses) |  |  | 50.00% |  |  |  |  |  |
Merus | Minimum |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales |  |  | 6.00% |  |  |  |  |  |
Merus | Minimum | United States |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales |  |  | 6.00% |  |  |  |  |  |
Merus | Maximum |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales |  |  | 10.00% |  |  |  |  |  |
Percentage of reverse royalty |  |  | 4.00% |  |  |  |  |  |
Merus | Maximum | United States |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales |  |  | 10.00% |  |  |  |  |  |
Percentage of additional royalties |  |  | 4.00% |  |  |  |  |  |
Merus | Maximum | Development and Regulatory Milestones |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |
Additional milestone payments under the license agreement |  |  | $ 100,000 |  |  |  |  |  |
Merus | Maximum | Commercialization Milestones |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |
Additional milestone payments under the license agreement |  |  | $ 250,000 |  |  |  |  |  |
Stock purchase agreement | Merus |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |
Purchase of common stock under Stock Purchase Agreement (in shares ) | shares |  |  |  | 3,200,000 |  |  |  |  |
Purchase price of common stock |  |  |  |  |  |  |  |  | $ 80,000
Per share price (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  | $ 25.00

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