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Income Taxes - Reconciliation of income taxes (Details) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Reconciliation of income taxes at the U.S. federal statutory rate to the provision for income taxes |  |  |
Provision (benefit) at U.S. federal statutory rate | $ 111,114 | $ 119,793 | $ (48,766)
State and local income taxes | 26,767 | 34,461 | (21,637)
Foreign tax rate differential | 13,670 | 55,171 | 30,839
Income tax credits | (30,505) | (55,139) | (38,221)
Change in valuation allowance | 67,056 | (523,279) | 158,815
Foreign-derived intangible income | (36,748) | (28,259) | (22,830)
Stock based compensation | 19,704 | 15,497 | 2,802
Acquisitions accounted for as research and development expenses | 14,700 | 0 | 0
Other | 2,698 | 3,618 | 2,477
Total provision (benefit) for income taxes | 188,456 | (378,137) | $ 63,479
Deferred tax assets: |  |  |
Net operating loss carry forwards | 182,193 | 137,935 |
Federal and state research credits | 17,141 | 206,184 |
Capitalized research and development | 265,140 | 59,247 |
Deferred revenue and accruals | 72,657 | 42,326 |
Non-cash compensation | 83,138 | 83,002 |
Acquisition-related contingent consideration | 30,483 | 31,450 |
Intangibles, net | 257,614 | 305,228 |
Long term investments | 54,662 | 34,733 |
Other | 9,600 | 15,991 |
Total gross deferred tax assets | 972,628 | 916,096 |
Less valuation allowance for deferred tax assets | (472,125) | (408,180) |
Net deferred tax assets | 500,503 | 507,916 |
Deferred tax liabilities: |  |  |
Property and equipment | (33,683) | (33,259) |
Other | (8,879) | (7,119) |
Total gross deferred tax liabilities | (42,562) | (40,378) |
Net deferred tax assets | $ 457,941 | $ 467,538 |

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