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License Agreements - Novartis (Details) - USD ($) $ in Thousands | 1 Months Ended | 12 Months Ended | 146 Months Ended
--- | --- | --- | ---
Apr. 30, 2022 | Apr. 30, 2016 | Nov. 30, 2009 | Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2021
License agreements |  |  |  |  |  |  |
Revenues |  |  |  | $ 3,394,635 | $ 2,986,267 | $ 2,666,702 |
United States |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |
Revenues |  |  |  | 3,200,000 | 2,900,000 | 2,600,000 |
JAKAFI |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |
Revenues |  |  |  | 2,409,225 | 2,134,508 | 1,937,850 |
Novartis |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |
Revenues |  |  |  | 60,000 | 0 | 170,000 |
Novartis | Development Milestones |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  | $ 157,000
Novartis | Development Milestones | Maximum |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  | $ 174,000 |  |  |  |
Novartis | Regulatory Milestones |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  | 340,000
Novartis | Regulatory Milestones | Maximum |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  | 495,000 |  |  |  |
Novartis | Commercialization Milestones |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  | 200,000
Novartis | Commercialization Milestones | Maximum |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  | $ 500,000 |  |  |  |
Novartis | GVHD | Development and Regulatory Milestones | Maximum |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  | $ 75,000 |  |  |  |  |
Novartis | JAKAVI |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |
Revenues |  |  |  | $ 331,600 | 338,000 | 277,900 |
Novartis | JAKAVI | Minimum |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |
Royalty payments on future global net sales |  |  |  | 12.00% |  |  |
Novartis | JAKAVI | Maximum |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |
Royalty payments on future global net sales |  |  |  | 14.00% |  |  |
Novartis | JAKAVI | Regulatory Milestones |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone | $ 45,000 |  |  |  |  |  |
Novartis | JAKAFI | United States |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |
Revenues |  |  |  | $ 113,100 | 99,600 | 89,900 |
Royalties payable |  |  |  | 253,500 | 148,100 |  | $ 148,100
Novartis | TABRECTA |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |
Revenues |  |  |  | $ 15,400 | $ 10,400 | $ 4,100 |
Novartis | TABRECTA | Regulatory Milestones |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone | $ 15,000 |  |  |  |  |  |

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