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License Agreements - Syndax (Details) - USD ($) $ / shares in Units, $ in Thousands, shares in Millions |  | 1 Months Ended | 12 Months Ended
--- | --- | --- | ---
Dec. 09, 2021 | Dec. 31, 2021 | Sep. 30, 2021 | Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
License agreements |  |  |  |  |  |
Purchase price of common stock |  |  |  |  |  | $ 150,000
Per share price (in dollars per share) |  |  |  |  |  | $ 41.33
Long term investments |  | $ 221,266 |  | $ 133,676 | $ 221,266 |
Research and development |  |  |  | 1,585,936 | 1,458,179 | $ 2,215,942
Unrealized (loss) gain on long term investments |  |  |  | (87,590) | (24,072) | $ 10,426
Investment in Syndax |  |  |  |  |  |
License agreements |  |  |  |  |  |
Purchase of common stock under Stock Purchase Agreement (in shares ) |  | 1.4 |  |  |  |
Purchase price of common stock | $ 35,000 | $ 35,000 |  |  | $ 35,000 |
Per share price (in dollars per share) | $ 17.48 | $ 24.62 |  |  | $ 24.62 |
Long term investments | $ 24,800 | $ 31,100 |  | 36,200 | $ 31,100 |
Research and development | $ 10,200 |  |  |  |  |
Unrealized (loss) gain on long term investments |  |  |  | $ 5,100 | 6,300 |
Syndax |  |  |  |  |  |
License agreements |  |  |  |  |  |
Upfront payment under license agreement |  |  |  |  | 117,000 |
Syndax | Development and Regulatory Milestones | Maximum |  |  |  |  |  |
License agreements |  |  |  |  |  |
Additional milestone payments under the license agreement |  | 220,000 |  |  | 220,000 |
Syndax | Commercialization Milestones | Maximum |  |  |  |  |  |
License agreements |  |  |  |  |  |
Additional milestone payments under the license agreement |  | $ 230,000 |  |  | $ 230,000 |
Syndax | Syndax | United States |  |  |  |  |  |
License agreements |  |  |  |  |  |
Funding of future development costs |  |  | 45.00% |  |  |
Syndax | Incyte | United States |  |  |  |  |  |
License agreements |  |  |  |  |  |
Funding of future development costs |  |  | 55.00% |  |  |

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