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License Agreements - Calithera (Details) $ / shares in Units, $ in Thousands | 1 Months Ended | 12 Months Ended |
--- | --- | --- | ---
Jun. 30, 2022 | Jan. 31, 2017 shares | Dec. 31, 2022 USD ($) | Dec. 31, 2021 USD ($) | Dec. 31, 2020 USD ($) $ / shares | Jan. 01, 2017 USD ($) $ / shares
License agreements |  |  |  |  |  |
Purchase price of common stock |  |  |  |  | $ 150,000 |
Per share price (in dollars per share) | $ / shares |  |  |  |  | $ 41.33 |
Long term investments |  |  | $ 133,676 | $ 221,266 |  |
Unrealized gain (loss) on long term investments |  |  | (87,590) | (24,072) | $ 10,426 |
Calithera |  |  |  |  |  |
License agreements |  |  |  |  |  |
Funding of future development costs |  | 70.00% |  |  |  |
Stock purchase agreement | Calithera |  |  |  |  |  |
License agreements |  |  |  |  |  |
Conversion ratio | 0.05 |  |  |  |  |
Calithera |  |  |  |  |  |
License agreements |  |  |  |  |  |
Long term investments |  |  | 300 | 1,100 |  |
Calithera | Other Comprehensive Income (Loss) |  |  |  |  |  |
License agreements |  |  |  |  |  |
Unrealized gain (loss) on long term investments |  |  | $ (900) | $ (7,300) | $ (1,400) |
Calithera | Stock purchase agreement |  |  |  |  |  |
License agreements |  |  |  |  |  |
Purchase of common stock under Stock Purchase Agreement (in shares ) | shares |  | 1,700,000 |  |  |  |
Purchase price of common stock |  |  |  |  |  | $ 8,000
Per share price (in dollars per share) | $ / shares |  |  |  |  |  | $ 4.65
Adjusted shares, stock split (in shares) | shares |  | 86,021 |  |  |  |

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