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Fair Value of Financial Instruments - Fair value on a recurring basis (Details)
$ in Thousands
12 Months Ended
Jun. 01, 2016
Dec. 31, 2022
USD ($)
Dec. 31, 2021
USD ($)
Dec. 31, 2020
USD ($)
Fair value of financial instruments        
Long term investments   $ 133,676 $ 221,266  
Roll forward of Level 3 liabilities        
Change in fair value of contingent consideration   $ 12,149 14,741 $ 23,385
ARIAD | Liability        
Roll forward of Level 3 liabilities        
Projected cash flows period 18 years      
ARIAD | Measurement Input, Discount Rate | Liability        
Roll forward of Level 3 liabilities        
Valuation input 0.10      
ARIAD | Measurement Input, Cap Rate | Liability        
Roll forward of Level 3 liabilities        
Valuation input   0.10    
ARIAD | Accrued and other current liabilities        
Roll forward of Level 3 liabilities        
Contingent consideration earned during the period but not yet paid   $ (9,300) (19,600)  
Significant Unobservable Inputs (Level 3) | Estimate of Fair Value Measurement        
Roll forward of Level 3 liabilities        
Balance at the beginning of the period   244,000 266,000  
Contingent consideration earned during the period but not yet paid   (9,286) (19,583)  
Payments made during the period   (25,863) (17,158)  
Change in fair value of contingent consideration   12,149 14,741  
Balance at the end of the period   221,000 244,000 $ 266,000
Fair Value, Recurring | Estimate of Fair Value Measurement        
Fair value of financial instruments        
Cash and cash equivalents   2,951,422 2,057,440  
Debt securities (government)   287,543 290,752  
Long term investments   133,676 221,266  
Total assets   3,372,641 2,569,458  
Acquisition-related contingent consideration   221,000 244,000  
Total liabilities   221,000 244,000  
Fair Value, Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1)        
Fair value of financial instruments        
Cash and cash equivalents   2,951,422 2,057,440  
Debt securities (government)   0 0  
Long term investments   133,676 221,266  
Total assets   3,085,098 2,278,706  
Acquisition-related contingent consideration   0 0  
Total liabilities   0 0  
Fair Value, Recurring | Significant Other Observable Inputs (Level 2)        
Fair value of financial instruments        
Cash and cash equivalents   0 0  
Debt securities (government)   287,543 290,752  
Long term investments   0 0  
Total assets   287,543 290,752  
Acquisition-related contingent consideration   0 0  
Total liabilities   0 0  
Fair Value, Recurring | Significant Unobservable Inputs (Level 3)        
Fair value of financial instruments        
Cash and cash equivalents   0 0  
Debt securities (government)   0 0  
Long term investments   0 0  
Total assets   0 0  
Acquisition-related contingent consideration   221,000 244,000  
Total liabilities   $ 221,000 $ 244,000