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License Agreements - Lily (Details) - USD ($) $ in Thousands	1 Months Ended				12 Months Ended			145 Months Ended
	Jun. 30, 2022	Mar. 31, 2022	May 31, 2019	Dec. 31, 2009	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2021	Mar. 31, 2017
License agreements
Revenues					$ 3,394,635	$ 2,986,267	$ 2,666,702
United States
License agreements
Revenues					3,200,000	2,900,000	2,600,000
Europe
License agreements
Revenues					147,000	124,100	105,000
Eli Lilly
License agreements
Revenues					70,000	50,000	30,000
Eli Lilly | Development Milestones
License agreements
Amount recognized and received for the achievement of a predefined milestone								$ 149,000
Eli Lilly | Development Milestones | Maximum
License agreements
Upfront and immediate milestone payment to be received under license agreement				$ 150,000
Eli Lilly | Regulatory Milestones
License agreements
Amount recognized and received for the achievement of a predefined milestone								335,000
Eli Lilly | Regulatory Milestones | Maximum
License agreements
Upfront and immediate milestone payment to be received under license agreement				365,000
Eli Lilly | Commercialization Milestones
License agreements
Amount recognized and received for the achievement of a predefined milestone								$ 50,000
Eli Lilly | Commercialization Milestones | Maximum
License agreements
Upfront and immediate milestone payment to be received under license agreement				$ 150,000
Eli Lilly | OLUMIANT
License agreements
Revenues					$ 134,500	$ 220,900	$ 110,900
Eli Lilly | OLUMIANT | Regulatory Milestones | United States
License agreements
Amount recognized and received for the achievement of a predefined milestone	$ 40,000
Eli Lilly | OLUMIANT | Regulatory Milestones | Europe
License agreements
Amount recognized and received for the achievement of a predefined milestone	20,000
Eli Lilly | OLUMIANT | Regulatory Milestones | Japan
License agreements
Amount recognized and received for the achievement of a predefined milestone	$ 10,000
Eli Lilly | GVHD
License agreements
Additional milestone payments under the license agreement									$ 40,000
Eli Lilly | GVHD | Regulatory Milestones
License agreements
Milestone payment made under license agreement			$ 20,000
Eli Lilly | GVHD | Regulatory Milestones | Europe
License agreements
Milestone payment made under license agreement		$ 20,000

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