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License Agreements - Calithera (Details) $ / shares in Units, $ in Thousands	1 Months Ended		12 Months Ended
	Jun. 30, 2022	Jan. 31, 2017 shares	Dec. 31, 2022 USD ($)	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($) $ / shares	Jan. 01, 2017 USD ($) $ / shares
License agreements
Purchase price of common stock					$ 150,000
Per share price (in dollars per share) | $ / shares					$ 41.33
Long term investments			$ 133,676	$ 221,266
Unrealized gain (loss) on long term investments			(87,590)	(24,072)	$ 10,426
Calithera
License agreements
Funding of future development costs		70.00%
Stock purchase agreement | Calithera
License agreements
Conversion ratio	0.05
Calithera
License agreements
Long term investments			300	1,100
Calithera | Other Comprehensive Income (Loss)
License agreements
Unrealized gain (loss) on long term investments			$ (900)	$ (7,300)	$ (1,400)
Calithera | Stock purchase agreement
License agreements
Purchase of common stock under Stock Purchase Agreement (in shares ) | shares		1,700,000
Purchase price of common stock						$ 8,000
Per share price (in dollars per share) | $ / shares						$ 4.65
Adjusted shares, stock split (in shares) | shares		86,021

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This element represents the aggregate cost of investments accounted for under the equity method of accounting.

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Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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