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License Agreements - MacroGenics (Details) - USD ($)
$ in Thousands
1 Months Ended 12 Months Ended
Jul. 31, 2022
Dec. 31, 2017
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2018
License agreements            
Research and development     $ 1,585,936 $ 1,458,179 $ 2,215,942  
MacroGenics            
License agreements            
Research and development     89,200 72,300 $ 59,000  
MacroGenics | Accrued Liabilities            
License agreements            
Accrued and other liabilities     2,900 $ 700    
Minimum | MacroGenics            
License agreements            
Royalty payments on future global net sales   15.00%        
Maximum | MacroGenics            
License agreements            
Royalty payments on future global net sales   24.00%        
Development Milestones | MacroGenics            
License agreements            
Milestone payment made under license agreement $ 30,000   $ 100,000      
Development and Regulatory Milestones | Maximum | MacroGenics            
License agreements            
Additional milestone payments under the license agreement $ 335,000          
Commercialization Milestones | Maximum | MacroGenics            
License agreements            
Additional milestone payments under the license agreement           $ 330,000