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License Agreements - Syros (Details) $ / shares in Units, $ in Thousands	1 Months Ended		12 Months Ended
	Sep. 30, 2022 shares	Jan. 31, 2018 USD ($) programTarget	Dec. 31, 2022 USD ($)	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($) $ / shares	Dec. 31, 2018 USD ($) $ / shares shares
License agreements
Purchase price of common stock					$ 150,000
Per share price (in dollars per share) | $ / shares					$ 41.33
Unrealized gain (loss) on long term investments			$ (87,590)	$ (24,072)	$ 10,426
Syros Pharmaceuticals, Inc.
License agreements
Number of program targets | programTarget		7
Fair value of shares on the issuance date			300	3,100
Unrealized gain (loss) on long term investments			$ (2,700)	$ (7,100)	$ 3,700
Syros Pharmaceuticals, Inc. | Stock purchase agreement
License agreements
Purchase of common stock under Stock Purchase Agreement (in shares ) | shares						800,000
Purchase price of common stock						$ 10,000
Per share price (in dollars per share) | $ / shares						$ 12.61
Syros Pharmaceuticals, Inc. | Amended stock purchase agreement
License agreements
Purchase of common stock under Stock Purchase Agreement (in shares ) | shares						100,000
Purchase price of common stock						$ 1,400
Per share price (in dollars per share) | $ / shares						$ 9.55
Syros Pharmaceuticals, Inc. | Maximum
License agreements
Target selection and option exercise fee payment		$ 54,000
Syros Pharmaceuticals, Inc. | Development and Regulatory Milestones | Maximum
License agreements
Additional milestone payments under the license agreement		50,000
Syros Pharmaceuticals, Inc. | Commercialization Milestones | Maximum
License agreements
Additional milestone payments under the license agreement		$ 65,000
Stock purchase agreement | Syros Pharmaceuticals, Inc.
License agreements
Conversion ratio	0.1
Investment owned (in shares) | shares	93,753

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