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License Agreements - Syndax (Details) - USD ($) $ / shares in Units, $ in Thousands, shares in Millions		1 Months Ended		12 Months Ended
	Dec. 09, 2021	Dec. 31, 2021	Sep. 30, 2021	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
License agreements
Purchase price of common stock						$ 150,000
Per share price (in dollars per share)						$ 41.33
Long term investments		$ 221,266		$ 133,676	$ 221,266
Research and development				1,585,936	1,458,179	$ 2,215,942
Unrealized (loss) gain on long term investments				(87,590)	(24,072)	$ 10,426
Investment in Syndax
License agreements
Purchase of common stock under Stock Purchase Agreement (in shares )		1.4
Purchase price of common stock	$ 35,000	$ 35,000			$ 35,000
Per share price (in dollars per share)	$ 17.48	$ 24.62			$ 24.62
Long term investments	$ 24,800	$ 31,100		36,200	$ 31,100
Research and development	$ 10,200
Unrealized (loss) gain on long term investments				$ 5,100	6,300
Syndax
License agreements
Upfront payment under license agreement					117,000
Syndax | Development and Regulatory Milestones | Maximum
License agreements
Additional milestone payments under the license agreement		220,000			220,000
Syndax | Commercialization Milestones | Maximum
License agreements
Additional milestone payments under the license agreement		$ 230,000			$ 230,000
Syndax | Syndax | United States
License agreements
Funding of future development costs			45.00%
Syndax | Incyte | United States
License agreements
Funding of future development costs			55.00%

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The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

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