XML 85 R73.htm IDEA: XBRL DOCUMENT v3.22.4
Income Taxes - Reconciliation of income taxes (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Reconciliation of income taxes at the U.S. federal statutory rate to the provision for income taxes      
Provision (benefit) at U.S. federal statutory rate $ 111,114 $ 119,793 $ (48,766)
State and local income taxes 26,767 34,461 (21,637)
Foreign tax rate differential 13,670 55,171 30,839
Income tax credits (30,505) (55,139) (38,221)
Change in valuation allowance 67,056 (523,279) 158,815
Foreign-derived intangible income (36,748) (28,259) (22,830)
Stock based compensation 19,704 15,497 2,802
Acquisitions accounted for as research and development expenses 14,700 0 0
Other 2,698 3,618 2,477
Total provision (benefit) for income taxes 188,456 (378,137) $ 63,479
Deferred tax assets:      
Net operating loss carry forwards 182,193 137,935  
Federal and state research credits 17,141 206,184  
Capitalized research and development 265,140 59,247  
Deferred revenue and accruals 72,657 42,326  
Non-cash compensation 83,138 83,002  
Acquisition-related contingent consideration 30,483 31,450  
Intangibles, net 257,614 305,228  
Long term investments 54,662 34,733  
Other 9,600 15,991  
Total gross deferred tax assets 972,628 916,096  
Less valuation allowance for deferred tax assets (472,125) (408,180)  
Net deferred tax assets 500,503 507,916  
Deferred tax liabilities:      
Property and equipment (33,683) (33,259)  
Other (8,879) (7,119)  
Total gross deferred tax liabilities (42,562) (40,378)  
Net deferred tax assets $ 457,941 $ 467,538