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Income Taxes - Tax Credit Carryforwards (Details) $ in Thousands	Dec. 31, 2022 USD ($)
Orphan drug tax credit carryforwards
Tax Credit Carryforward
Tax credit carryforward	$ 14,641
State
Tax Credit Carryforward
Net operating loss carryforwards	257,806
State | Research and development credit carryforwards
Tax Credit Carryforward
Tax credit carryforward	20,773
Foreign
Tax Credit Carryforward
Net operating loss carryforwards	$ 1,692,283

X

- Definition

Amount of operating loss carryforward, before tax effects, available to reduce future taxable income under enacted tax laws.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 3
-Subparagraph (a)
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The amount of the tax credit carryforward, before tax effects, available to reduce future taxable income under enacted tax laws.

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