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CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($)
shares in Thousands, $ in Thousands
3 Months Ended
Mar. 31, 2023
Mar. 31, 2022
Revenues:    
Total revenues $ 808,673 $ 733,235
Costs and expenses:    
Cost of product revenues (including definite-lived intangible amortization) 56,822 42,614
Research and development 406,641 353,373
Selling, general and administrative 315,606 209,584
Loss on change in fair value of acquisition-related contingent consideration 6,196 6,382
(Profit) and loss sharing under collaboration agreements (1,362) 4,742
Total costs and expenses 783,903 616,695
Income from operations 24,770 116,540
Interest income and other, net 32,873 1,260
Interest expense (469) (680)
Unrealized loss on long term investments (5,318) (46,585)
Income before provision for income taxes 51,856 70,535
Provision for income taxes 30,153 32,543
Net income $ 21,703 $ 37,992
Net income per share:    
Basic (in USD per share) $ 0.10 $ 0.17
Diluted (in USD per share) $ 0.10 $ 0.17
Shares used in computing net income per share:    
Basic (in shares) 222,960 221,326
Diluted (in shares) 225,589 222,950
Product revenues, net    
Revenues:    
Total revenues $ 693,237 $ 605,821
Product royalty revenues    
Revenues:    
Total revenues 115,436 122,414
Milestone and contract revenues    
Revenues:    
Total revenues $ 0 $ 5,000