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License Agreements - Syros (Details) $ in Thousands	1 Months Ended	3 Months Ended
	Jan. 31, 2018 USD ($) item	Mar. 31, 2023 USD ($) shares	Mar. 31, 2022 USD ($)	Dec. 31, 2022 USD ($)
License Agreements
Fair market long term investments		$ 128,313		$ 133,676	[1]
Unrealized gain (loss) on long term investments		$ (5,318)	$ (46,585)
Syros Pharmaceuticals, Inc.
License Agreements
Common stock held from investment (in shares) | shares		93,753
Fair market long term investments		$ 300		$ 300
Unrealized gain (loss) on long term investments		$ (100)	$ (1,900)
Syros Pharmaceuticals, Inc.
License Agreements
Number of program targets | item	7
Syros Pharmaceuticals, Inc. | Maximum
License Agreements
Target selection and option exercise fee payment	$ 54,000
Syros Pharmaceuticals, Inc. | Maximum | Development and Regulatory Milestones
License Agreements
Additional milestone payments under the license agreement	50,000
Syros Pharmaceuticals, Inc. | Maximum | Commercialization Milestones
License Agreements
Additional milestone payments under the license agreement	$ 65,000
[1] The condensed consolidated balance sheet at December 31, 2022 has been derived from the audited consolidated financial statements at that date.

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