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License Agreements - Syndax (Details) - USD ($) $ in Thousands	1 Months Ended		3 Months Ended
	Dec. 31, 2021	Sep. 30, 2021	Mar. 31, 2023	Mar. 31, 2022	Dec. 31, 2022
License Agreements
Fair market long term investments			$ 128,313		$ 133,676	[1]
Research and development			406,641	$ 353,373
Unrealized gain (loss) on long term investments			$ (5,318)	(46,585)
Investment in Syndax
License Agreements
Common stock held from investment (in shares)			1,400,000
Fair market long term investments			$ 30,000		$ 36,200
Unrealized gain (loss) on long term investments			(6,200)	$ (6,400)
Syndax
License Agreements
Upfront payment under license agreement	$ 117,000
Syndax | Development and Regulatory Milestones | Maximum
License Agreements
Additional milestone payments under the license agreement			220,000
Syndax | Commercialization Milestones | Maximum
License Agreements
Additional milestone payments under the license agreement			$ 230,000
UNITED STATES | Syndax | Syndax
License Agreements
Funding of future development costs (as a percent)		45.00%
UNITED STATES | Syndax | Incyte
License Agreements
Funding of future development costs (as a percent)		55.00%
[1] The condensed consolidated balance sheet at December 31, 2022 has been derived from the audited consolidated financial statements at that date.

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The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

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